Relationship of obesity and neurodegeneration: therapeutic potential of anorexigenic neuropeptides

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F25%3A00639669" target="_blank" >RIV/61388963:_____/25:00639669 - isvavai.cz</a>

Výsledek na webu

<a href="https://hdl.handle.net/11104/0370135" target="_blank" >https://hdl.handle.net/11104/0370135</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Relationship of obesity and neurodegeneration: therapeutic potential of anorexigenic neuropeptides

Popis výsledku v původním jazyce

Recently discovered anorexigenic neuropeptides, such as prolactin-releasing peptide (PrRP) and cocaine- and amphetamine-regulated transcript (CART) peptide, represent new trends in development of anti-obesity and glucose-lowering, as well as neuroprotective compounds. Neuropeptides are released and acting directly in brain areas regulating food intake, but generally do not cross the blood-brain barrier if administered peripherally. We succeeded to design stable lipidized PrRP and CART peptide analogs with prolonged acute anorexigenic effect after peripheral administration in mice and rats. Repeated peripheral administration of the lipidized analogs resulted in long-lasting anti-obesity and antidiabetic effects in mouse models of diet induced obesity and insulin resistance. We showed that lipidization of anorexigenic peptides might be an effective way to increase stability and exert the effect to the central nervous system after peripheral administration in preclinical rodent models, for a potential treatment of obesity and related complications such as Type 2 diabetes and neurodegeneration.n

Název v anglickém jazyce

Relationship of obesity and neurodegeneration: therapeutic potential of anorexigenic neuropeptides

Popis výsledku anglicky

Recently discovered anorexigenic neuropeptides, such as prolactin-releasing peptide (PrRP) and cocaine- and amphetamine-regulated transcript (CART) peptide, represent new trends in development of anti-obesity and glucose-lowering, as well as neuroprotective compounds. Neuropeptides are released and acting directly in brain areas regulating food intake, but generally do not cross the blood-brain barrier if administered peripherally. We succeeded to design stable lipidized PrRP and CART peptide analogs with prolonged acute anorexigenic effect after peripheral administration in mice and rats. Repeated peripheral administration of the lipidized analogs resulted in long-lasting anti-obesity and antidiabetic effects in mouse models of diet induced obesity and insulin resistance. We showed that lipidization of anorexigenic peptides might be an effective way to increase stability and exert the effect to the central nervous system after peripheral administration in preclinical rodent models, for a potential treatment of obesity and related complications such as Type 2 diabetes and neurodegeneration.n

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/LX22NPO5104" target="_blank" >LX22NPO5104: Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů