Development of hydrophilic polymer conjugates and molecular probes as antibody mimetics for biomedical applications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F25%3A00639892" target="_blank" >RIV/61388963:_____/25:00639892 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Development of hydrophilic polymer conjugates and molecular probes as antibody mimetics for biomedical applications

Popis výsledku v původním jazyce

Recently developed synthetic polymer conjugates of N-(2-hydroxypropyl) methacrylamide (HPMA) in combination with low-molecular-weight ligands, called iBodies, alongside with small molecular probes, represent a promising alternative to conventional antibodies. iBodies constitute a novel class of antibody mimetics that target specific molecules through selective low-molecular-weight ligands. The biocompatible, stable, and easily modifiable HPMA polymer backbone can be designed and synthesized to target diverse molecules with known ligands, providing an extremely flexible platform with broad potential applications. An alternative targeting approach employs small probes based on polyethylene glycol (PEG) linkers conjugated with identical low-molecular-weight ligands. This dissertation thesis aims to explore the application of such polymer conjugates and probes as antibody mimetics in research, therapy, and diagnostics, with particular emphasis on cancer. The work focuses on selection of appropriate targets (tumor markers and relevant immune system receptors), identification or design of specific low-molecular-weight ligands for these target molecules, and their subsequent characterization using established in vitro methods from protein biochemistry and molecular biology. The ultimate goal is to develop new iBodies and probes for biomedical applications including visualization, isolation, and potential experimental therapy of cancer.nThis work was supported by the project National Institute for Cancer Research (Programme EXCELES, ID Project No. LX22NPO5102) - Funded by the European Union - NextGenerationEU.n

Název v anglickém jazyce

Development of hydrophilic polymer conjugates and molecular probes as antibody mimetics for biomedical applications

Popis výsledku anglicky

Recently developed synthetic polymer conjugates of N-(2-hydroxypropyl) methacrylamide (HPMA) in combination with low-molecular-weight ligands, called iBodies, alongside with small molecular probes, represent a promising alternative to conventional antibodies. iBodies constitute a novel class of antibody mimetics that target specific molecules through selective low-molecular-weight ligands. The biocompatible, stable, and easily modifiable HPMA polymer backbone can be designed and synthesized to target diverse molecules with known ligands, providing an extremely flexible platform with broad potential applications. An alternative targeting approach employs small probes based on polyethylene glycol (PEG) linkers conjugated with identical low-molecular-weight ligands. This dissertation thesis aims to explore the application of such polymer conjugates and probes as antibody mimetics in research, therapy, and diagnostics, with particular emphasis on cancer. The work focuses on selection of appropriate targets (tumor markers and relevant immune system receptors), identification or design of specific low-molecular-weight ligands for these target molecules, and their subsequent characterization using established in vitro methods from protein biochemistry and molecular biology. The ultimate goal is to develop new iBodies and probes for biomedical applications including visualization, isolation, and potential experimental therapy of cancer.nThis work was supported by the project National Institute for Cancer Research (Programme EXCELES, ID Project No. LX22NPO5102) - Funded by the European Union - NextGenerationEU.n

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/LX22NPO5102" target="_blank" >LX22NPO5102: Národní ústav pro výzkum rakoviny</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů