Laterální kompartmentace proteinů a lipidů v plasmatické membráně: Role membránového potenciálu

Kód výsledku v IS VaVaI

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Nalezeny alternativní kódy

RIV/68378041:_____/07:00097541

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Lateral Compartmenation of Proteins and Lipids in the Plasma Membrane: Involvement of the Membrane Potential

Popis výsledku v původním jazyce

The membrane potential is mainly considered as the driving force for ion and nutrient translocation. We have discovered a novel role of the membrane potential in the organization of the plasma membrane. Within the yeast plasma membrane, two non-overlapping sub-compartements have been visualized (1). The first one, represented by a network-like structure, is occupied by the proton ATPase, Pma1, and the second one, forming 300 nm patches, houses a number of proton symporters (Can1, Fur4, Tat2) and the Sur7-protein. We show that sterols, the main lipid constituent of the plasma membrane, also accumulate within the patchy compartment (2). This compartmentation is highly dependent on energization. Membrane depolarization causes reversible dispersion of theH+-symporters, not however of the Sur7 protein. Mitochondrial mutants affected in the plasma membrane energization, show a significantly lower degree of membrane protein segregation

Název v anglickém jazyce

Lateral Compartmenation of Proteins and Lipids in the Plasma Membrane: Involvement of the Membrane Potential

Popis výsledku anglicky

The membrane potential is mainly considered as the driving force for ion and nutrient translocation. We have discovered a novel role of the membrane potential in the organization of the plasma membrane. Within the yeast plasma membrane, two non-overlapping sub-compartements have been visualized (1). The first one, represented by a network-like structure, is occupied by the proton ATPase, Pma1, and the second one, forming 300 nm patches, houses a number of proton symporters (Can1, Fur4, Tat2) and the Sur7-protein. We show that sterols, the main lipid constituent of the plasma membrane, also accumulate within the patchy compartment (2). This compartmentation is highly dependent on energization. Membrane depolarization causes reversible dispersion of theH+-symporters, not however of the Sur7 protein. Mitochondrial mutants affected in the plasma membrane energization, show a significantly lower degree of membrane protein segregation

Druh

D - Stať ve sborníku

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Annual Conference on Yeasts /35./. Programme. Abstracts

ISBN

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ISSN

1336-4839

e-ISSN

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Počet stran výsledku

1

Strana od-do

34-34

Název nakladatele

SAS

Místo vydání

Bratislava

Místo konání akce

Smolenice

Datum konání akce

16. 5. 2007

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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