8-izoprostan a leukotrieny v kondenzátu vydechovaného vzduchu u českých osob se silikózou

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F07%3A00099036" target="_blank" >RIV/61388971:_____/07:00099036 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/07:00008874

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

8-Isoprostane and leukotrienes in exhaled breath condensate in czech subjects with silicosis

Popis výsledku v původním jazyce

Silicosis has progressive, but unpredictable development. There are no markers routinely available to measure the activity and prognosis of silicosis. 8-isoprostane, a marker of oxidative stress and leukotrienes B4, C4, D4, and E4 were measured in exhaled breath condensate in patients with silicosis. Sixty subjects were examined, with mean age 66.7 +/- 2.0 yr and mean exposure to silica 23.6 +/- 2.5 yr. The control group had 25 subjects, with mean age 64.7 +/- 4.8 yr. Exhaled breath was collected usingthe EcoScreen (Jaeger, Germany); 8-isoprostane and leukotrienes were analyzed by high-performance liquid hromatography/mass spectrometry. Several lung functions parameters were impaired in silicotics in comparisons with the controls; ESR, .alpha.1-antitrypsin and proteinuria were higher in the silicotics. Antineutrophilic cytoplasmic antibodies were more frequent in the silicotics (39%) than in the controls (4%), (p=0.0017).

Název v anglickém jazyce

8-Isoprostane and leukotrienes in exhaled breath condensate in czech subjects with silicosis

Popis výsledku anglicky

Silicosis has progressive, but unpredictable development. There are no markers routinely available to measure the activity and prognosis of silicosis. 8-isoprostane, a marker of oxidative stress and leukotrienes B4, C4, D4, and E4 were measured in exhaled breath condensate in patients with silicosis. Sixty subjects were examined, with mean age 66.7 +/- 2.0 yr and mean exposure to silica 23.6 +/- 2.5 yr. The control group had 25 subjects, with mean age 64.7 +/- 4.8 yr. Exhaled breath was collected usingthe EcoScreen (Jaeger, Germany); 8-isoprostane and leukotrienes were analyzed by high-performance liquid hromatography/mass spectrometry. Several lung functions parameters were impaired in silicotics in comparisons with the controls; ESR, .alpha.1-antitrypsin and proteinuria were higher in the silicotics. Antineutrophilic cytoplasmic antibodies were more frequent in the silicotics (39%) than in the controls (4%), (p=0.0017).

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/NR8107" target="_blank" >NR8107: Zjišťování oxidativního stresu u osob s expozicí fibrogenním prachům.</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Industrial Health

ISSN

0019-8366

e-ISSN

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Svazek periodika

45

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

JP - Japonsko

Počet stran výsledku

9

Strana od-do

766-774

Kód UT WoS článku

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EID výsledku v databázi Scopus

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