Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquid media and evaluation of their antitumor proliferative aktivity

Kód výsledku v IS VaVaI

RIV/61388971:_____/09:00328344 - isvavai.cz

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquid media and evaluation of their antitumor proliferative aktivity

Popis výsledku v původním jazyce

Biocatalytic preparation of acylated derivatives of silybin using several acyl donors (free fatty acids or their esters), catalyzed by immobilized Candida antarctica lipase B, was performed in various organic solvents as well as in imidazolium-based ionic liquids containing either BF-4 or PF-6 anions. Total conversion of silybin was achieved in acetone using short-chain acyl donors (vinyl butanoate) at a 10:1 molar ratio of acyl donor to silybin. The enzymatic process in ionic liquids depended stronglyon the alkyl chain length of the cation as well the anion used. Higher conversion yields (up to 75.8 percent) and reaction rates (up to 0.31 mmol h-1 g-1 biocatalyst) were obtained in the BF-4 as compared with PF-6 - containing ionic liquids

Název v anglickém jazyce

Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquid media and evaluation of their antitumor proliferative aktivity

Popis výsledku anglicky

Biocatalytic preparation of acylated derivatives of silybin using several acyl donors (free fatty acids or their esters), catalyzed by immobilized Candida antarctica lipase B, was performed in various organic solvents as well as in imidazolium-based ionic liquids containing either BF-4 or PF-6 anions. Total conversion of silybin was achieved in acetone using short-chain acyl donors (vinyl butanoate) at a 10:1 molar ratio of acyl donor to silybin. The enzymatic process in ionic liquids depended stronglyon the alkyl chain length of the cation as well the anion used. Higher conversion yields (up to 75.8 percent) and reaction rates (up to 0.31 mmol h-1 g-1 biocatalyst) were obtained in the BF-4 as compared with PF-6 - containing ionic liquids

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

—

Projekt

ME 922: Chemoenzymové modifikace flavonoidů ? příprava nových hybridních antioxidantů se zvýšenými antiradikálovými a protizánětlivými účinky.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biocatalysis and Biotransformation

ISSN

1024-2422

e-ISSN

—

Svazek periodika

27

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

—

Kód UT WoS článku

000268032500001

EID výsledku v databázi Scopus

—