Targed neural stem cell differentiation and related cell based therapy in spinal cord injury

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F09%3A00330776" target="_blank" >RIV/61388971:_____/09:00330776 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985904:_____/09:00330776

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Targed neural stem cell differentiation and related cell based therapy in spinal cord injury

Popis výsledku v původním jazyce

Transplantation of stem cells represents a unique approach to treat spinal trauma. To follow in vivo traumatic changes, the signalling proteins were studied in the rat spinal cord transsection. 80th motoneurons and sensory neurons were subjected to analysis. Computer modeling of protein changes indicates that downregulated proteins belong to oxidative stress response as well as cellular fate and organisation. Increase of proteins involved in genome maintenance was observed in ventral horns. Only marginal changes were found in the dorsal root ganglia. To characterise mechanisms governing differentiation we combined the porcine neural stem cells in vitro differentiation and complementary proteomic analyses. The stem cells exhibited high levels of GRK2 and several members of FAS pathway. Typical for differentiated neural cells were enhanced integrin, PDGF and MAP kinase signalling and heme-oxygenase 2. Characterisation of changes related to cell differentiation helps to define suitab

Název v anglickém jazyce

Targed neural stem cell differentiation and related cell based therapy in spinal cord injury

Popis výsledku anglicky

Transplantation of stem cells represents a unique approach to treat spinal trauma. To follow in vivo traumatic changes, the signalling proteins were studied in the rat spinal cord transsection. 80th motoneurons and sensory neurons were subjected to analysis. Computer modeling of protein changes indicates that downregulated proteins belong to oxidative stress response as well as cellular fate and organisation. Increase of proteins involved in genome maintenance was observed in ventral horns. Only marginal changes were found in the dorsal root ganglia. To characterise mechanisms governing differentiation we combined the porcine neural stem cells in vitro differentiation and complementary proteomic analyses. The stem cells exhibited high levels of GRK2 and several members of FAS pathway. Typical for differentiated neural cells were enhanced integrin, PDGF and MAP kinase signalling and heme-oxygenase 2. Characterisation of changes related to cell differentiation helps to define suitab

Druh

D - Stať ve sborníku

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

<a href="/cs/project/1M0538" target="_blank" >1M0538: Centrum buněčné terapie a tkáňových náhrad</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

3rd Central and Eastern Proteomics Conference, 2009

ISBN

978-963-9319-99-8

ISSN

—

e-ISSN

—

Počet stran výsledku

1

Strana od-do

—

Název nakladatele

Hungarian proteomic society

Místo vydání

Budapest

Místo konání akce

Budapešť

Datum konání akce

6. 10. 2009

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

—