Ovarian hyperstimulation syndrome biomarker(s) search in human follicular fluid

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F09%3A00338300" target="_blank" >RIV/61388971:_____/09:00338300 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985904:_____/09:00338300

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Ovarian hyperstimulation syndrome biomarker(s) search in human follicular fluid

Popis výsledku v původním jazyce

Ovarian hyperstimulation syndrome (OHSS) is a serious complication of in vitro fertilisation therapy using hormonal stimulation of ovaries. Current diagnosis is not sufficient and could be significantly improved if a protein biomarker(s) could be identified in patient follicular fluid (HFF). In search for new potential diagnostic and prognostic biomarker(s) of OHSS we have used a combination of immunoaffinity depletion, 2-D LC and 2-DE to obtain 2D protein profiles of HFF from OHSS positive and OHSS negative women. The protein maps were evaluated using software tools and protein spots or bands significantly increased or decreased in HFF of OHSS positive and OHSS negative women were identified using MS. In total, we identified 20 proteins and 3 of themwere shared between two different 2D technologies. Most of the identified proteins belong to different functional groups including the complement cascade, transport, blood coagulation, acute phase response and inflammation.

Název v anglickém jazyce

Ovarian hyperstimulation syndrome biomarker(s) search in human follicular fluid

Popis výsledku anglicky

Ovarian hyperstimulation syndrome (OHSS) is a serious complication of in vitro fertilisation therapy using hormonal stimulation of ovaries. Current diagnosis is not sufficient and could be significantly improved if a protein biomarker(s) could be identified in patient follicular fluid (HFF). In search for new potential diagnostic and prognostic biomarker(s) of OHSS we have used a combination of immunoaffinity depletion, 2-D LC and 2-DE to obtain 2D protein profiles of HFF from OHSS positive and OHSS negative women. The protein maps were evaluated using software tools and protein spots or bands significantly increased or decreased in HFF of OHSS positive and OHSS negative women were identified using MS. In total, we identified 20 proteins and 3 of themwere shared between two different 2D technologies. Most of the identified proteins belong to different functional groups including the complement cascade, transport, blood coagulation, acute phase response and inflammation.

Druh

D - Stať ve sborníku

CEP obor

FK - Gynekologie a porodnictví

OECD FORD obor

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Projekt

<a href="/cs/project/1QS500450568" target="_blank" >1QS500450568: Samičí pohlavní buňky - regulace jejich meiotické a vývojové kompetence a možnosti jejího praktického využití</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

3rd Central and Eastern Proteomics Conference, 2009

ISBN

978-963-9319-99-8

ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

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Název nakladatele

Hungarian proteomic society

Místo vydání

Budapest

Místo konání akce

Budapešť

Datum konání akce

6. 10. 2009

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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