From models to pathogens: how much have we learned about Streptococcus pneumoniae cell division?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00424455" target="_blank" >RIV/61388971:_____/13:00424455 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1111/1462-2920.12189" target="_blank" >http://dx.doi.org/10.1111/1462-2920.12189</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/1462-2920.12189" target="_blank" >10.1111/1462-2920.12189</a>

Jazyk výsledku

angličtina

Název v původním jazyce

From models to pathogens: how much have we learned about Streptococcus pneumoniae cell division?

Popis výsledku v původním jazyce

Streptococcus pneumoniae is an oval-shaped Gram-positive coccus that lives in intimate association with its human host, both as a commensal and pathogen. The seriousness of pneumococcal infections and the spread of multi-drug resistant strains call for new lines of intervention. Bacterial cell division is an attractive target to develop antimicrobial drugs. This review discusses the recent advances in understanding S.pneumoniae growth and division, in comparison with the best studied rod-shaped models,Escherichia coli and Bacillus subtilis. To maintain their shape, these bacteria propagate by peripheral and septal peptidoglycan synthesis, involving proteins that assemble into distinct complexes called the elongasome and the divisome, respectively. Many of these proteins are conserved in S.pneumoniae, supporting the notion that the ovococcal shape is also achieved by rounds of elongation and division. Importantly, S.pneumoniae and close relatives with similar morphology differ in sever

Název v anglickém jazyce

From models to pathogens: how much have we learned about Streptococcus pneumoniae cell division?

Popis výsledku anglicky

Streptococcus pneumoniae is an oval-shaped Gram-positive coccus that lives in intimate association with its human host, both as a commensal and pathogen. The seriousness of pneumococcal infections and the spread of multi-drug resistant strains call for new lines of intervention. Bacterial cell division is an attractive target to develop antimicrobial drugs. This review discusses the recent advances in understanding S.pneumoniae growth and division, in comparison with the best studied rod-shaped models,Escherichia coli and Bacillus subtilis. To maintain their shape, these bacteria propagate by peripheral and septal peptidoglycan synthesis, involving proteins that assemble into distinct complexes called the elongasome and the divisome, respectively. Many of these proteins are conserved in S.pneumoniae, supporting the notion that the ovococcal shape is also achieved by rounds of elongation and division. Importantly, S.pneumoniae and close relatives with similar morphology differ in sever

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Microbiology

ISSN

1462-2912

e-ISSN

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Svazek periodika

15

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

25

Strana od-do

3133-3157

Kód UT WoS článku

000327711100003

EID výsledku v databázi Scopus

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