Biotransformation of the Antibiotic Agent Flumequine by Ligninolytic Fungi and Residual Antibacterial Activity of the Transformation Mixtures

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00424855" target="_blank" >RIV/61388971:_____/13:00424855 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1021/es403470s" target="_blank" >http://dx.doi.org/10.1021/es403470s</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/es403470s" target="_blank" >10.1021/es403470s</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biotransformation of the Antibiotic Agent Flumequine by Ligninolytic Fungi and Residual Antibacterial Activity of the Transformation Mixtures

Popis výsledku v původním jazyce

Flumequine, a fluoroquinolone antibiotic, is applied preferably in veterinary medicine, for stock breeding and treatment of aquacultures. Formation of drug resistance is a matter of general concern when antibiotics such as flumquine occur in the environment. Thus, biodegradation of flumequine in solution was investigated using five different ligninolytic fungi. Irpex lacteus, Dichomitus squalens, and Trametes versicolor proved most efficient and transformed more than 90% of flumequine within 6 or even 3days. Pan us tigrinus and Pleurotus ostreatus required up to 14 days to remove >90% of flumequine. Analyses of the metabolites by liquid chromatography mass spectrometry suggest different transformation pathways for the different fungal strains. Structure proposals were elaborated for 8 metabolites. 7-Hydroxy-flumequine and flumequine ethyl ester were identified as common metabolites produced by all ligninolytic fungi. The largest variety of metabolites was formed by D. squalens. Residu

Název v anglickém jazyce

Biotransformation of the Antibiotic Agent Flumequine by Ligninolytic Fungi and Residual Antibacterial Activity of the Transformation Mixtures

Popis výsledku anglicky

Flumequine, a fluoroquinolone antibiotic, is applied preferably in veterinary medicine, for stock breeding and treatment of aquacultures. Formation of drug resistance is a matter of general concern when antibiotics such as flumquine occur in the environment. Thus, biodegradation of flumequine in solution was investigated using five different ligninolytic fungi. Irpex lacteus, Dichomitus squalens, and Trametes versicolor proved most efficient and transformed more than 90% of flumequine within 6 or even 3days. Pan us tigrinus and Pleurotus ostreatus required up to 14 days to remove >90% of flumequine. Analyses of the metabolites by liquid chromatography mass spectrometry suggest different transformation pathways for the different fungal strains. Structure proposals were elaborated for 8 metabolites. 7-Hydroxy-flumequine and flumequine ethyl ester were identified as common metabolites produced by all ligninolytic fungi. The largest variety of metabolites was formed by D. squalens. Residu

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

<a href="/cs/project/TE01020218" target="_blank" >TE01020218: Ekologicky šetrné nanotechnologie a biotechnologie pro čištění vod a půd</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Science and Technology

ISSN

0013-936X

e-ISSN

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Svazek periodika

47

Číslo periodika v rámci svazku

24

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

14128-14136

Kód UT WoS článku

000328796900028

EID výsledku v databázi Scopus

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