The enigma of the lower gut-associated lymphoid tissue (GALT)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00425461" target="_blank" >RIV/61388971:_____/13:00425461 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1189/jlb.0313120" target="_blank" >http://dx.doi.org/10.1189/jlb.0313120</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1189/jlb.0313120" target="_blank" >10.1189/jlb.0313120</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The enigma of the lower gut-associated lymphoid tissue (GALT)

Popis výsledku v původním jazyce

Review of specialized hind-gut lymphoid tissue, and its necessity for systemic B cell development/diversification early in life. Artiodactyls possess GALT that appears in fetal life and is located at the extreme end of the ileum. These IPP contain mostlyB cells and involute early in postnatal life. Rabbits have a similarly located lymphoid organ, called the sacculus rotundus. Studies in sheep and rabbits have led to the concept that the lower hindgut GALT represents primary lymphoid tissue for B cellsand is necessary for normal B cell development, analogous to the bursa of Fabricius. This review traces the history of the observations and theories that have led to the existing concept concerning the role of lower GALT. We then review recent data frompiglets with resected IPP that challenges the concept that the IPP is primary B cell lymphoid tissue and that artiodactyls and rabbits are members of the GALT group in the same context as gallinaceous birds. Eliminating the IPP as the pri

Název v anglickém jazyce

The enigma of the lower gut-associated lymphoid tissue (GALT)

Popis výsledku anglicky

Review of specialized hind-gut lymphoid tissue, and its necessity for systemic B cell development/diversification early in life. Artiodactyls possess GALT that appears in fetal life and is located at the extreme end of the ileum. These IPP contain mostlyB cells and involute early in postnatal life. Rabbits have a similarly located lymphoid organ, called the sacculus rotundus. Studies in sheep and rabbits have led to the concept that the lower hindgut GALT represents primary lymphoid tissue for B cellsand is necessary for normal B cell development, analogous to the bursa of Fabricius. This review traces the history of the observations and theories that have led to the existing concept concerning the role of lower GALT. We then review recent data frompiglets with resected IPP that challenges the concept that the IPP is primary B cell lymphoid tissue and that artiodactyls and rabbits are members of the GALT group in the same context as gallinaceous birds. Eliminating the IPP as the pri

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Leukocyte Biology

ISSN

0741-5400

e-ISSN

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Svazek periodika

94

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

259-270

Kód UT WoS článku

000329744300007

EID výsledku v databázi Scopus

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