The invertebrate immune system as a model for investigating the environmental impact of nanoparticles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F13%3A00425739" target="_blank" >RIV/61388971:_____/13:00425739 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The invertebrate immune system as a model for investigating the environmental impact of nanoparticles

Popis výsledku v původním jazyce

Invertebrates lack an adaptive immunity; however, they are endowed with a potent and complex innate immune system similar to that of vertebrates. In most invertebrates, free circulating cells (hemocytes) are responsible for cell-mediated immunity; when activated, different hemocyte types are capable of phagocytosis, reactive oxygen species and NO production, release of hydrolytic enzymes and antimicrobial peptides. Conservation of the general mechanisms of innate immunity from invertebrates to mammals is useful for the evaluation of the environmental impact of nanoparticles. The mechanisms of innate immunity in two model representatives of aquatic (bivalves) and terrestrial (earthworms) environments are summarized, and data supporting the view that cell-mediated immunity can represent the primary target of nanoparticles in invertebrates are presented. The evaluation of immune parameters in invertebrate models may represent a powerful tool for the rapid screening of the immunomodulatory

Název v anglickém jazyce

The invertebrate immune system as a model for investigating the environmental impact of nanoparticles

Popis výsledku anglicky

Invertebrates lack an adaptive immunity; however, they are endowed with a potent and complex innate immune system similar to that of vertebrates. In most invertebrates, free circulating cells (hemocytes) are responsible for cell-mediated immunity; when activated, different hemocyte types are capable of phagocytosis, reactive oxygen species and NO production, release of hydrolytic enzymes and antimicrobial peptides. Conservation of the general mechanisms of innate immunity from invertebrates to mammals is useful for the evaluation of the environmental impact of nanoparticles. The mechanisms of innate immunity in two model representatives of aquatic (bivalves) and terrestrial (earthworms) environments are summarized, and data supporting the view that cell-mediated immunity can represent the primary target of nanoparticles in invertebrates are presented. The evaluation of immune parameters in invertebrate models may represent a powerful tool for the rapid screening of the immunomodulatory

Druh

C - Kapitola v odborné knize

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/EE2.3.20.0055" target="_blank" >EE2.3.20.0055: Tvorba týmů pro Centrum mikrobiologie a imunologie</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Nanoparticles and the Immune System

ISBN

978-0-12-408085-0

Počet stran výsledku

22

Strana od-do

91-112

Počet stran knihy

138

Název nakladatele

Academic Press, Elsevier Inc

Místo vydání

Oxford

Kód UT WoS kapitoly

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