The comparative profile of lymphoid cells and the T and B cell spectratype of germ-free piglets infected with viruses SIV, PRRSV or PCV2

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F14%3A00435549" target="_blank" >RIV/61388971:_____/14:00435549 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1186/s13567-014-0091-x" target="_blank" >http://dx.doi.org/10.1186/s13567-014-0091-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13567-014-0091-x" target="_blank" >10.1186/s13567-014-0091-x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The comparative profile of lymphoid cells and the T and B cell spectratype of germ-free piglets infected with viruses SIV, PRRSV or PCV2

Popis výsledku v původním jazyce

Lymphocyte subsets isolated from germ-free piglets experimentally infected with swine influenza virus (SIV), porcine reproductive and respiratory syndrome virus (PRRSV) or porcine circovirus type 2 (PCV2) were studied and the profile of these subsets among these three infections was monitored. Germ-free piglets were used since their response could be directly correlated to the viral infection. Because SIV infections are resolved even by colostrum-deprived neonates whereas PRRSV and PCV2 infections are not, SIV was used as a benchmark for an effectively resolved viral infection. PRRSV caused a large increase in the proportion of lymphocytes at the site of infection and rapid differentiation of B cells leading to a high level of Ig-producing cells but asevere reduction in CD2(-)CD21(+) primed B cells. Unlike SIV and PCV2, PRRSV also caused an increase in terminally differentiated subset of CD2(+)CD8 alpha(+) gamma delta cells and polyclonal expansion of major V beta families suggesting

Název v anglickém jazyce

The comparative profile of lymphoid cells and the T and B cell spectratype of germ-free piglets infected with viruses SIV, PRRSV or PCV2

Popis výsledku anglicky

Lymphocyte subsets isolated from germ-free piglets experimentally infected with swine influenza virus (SIV), porcine reproductive and respiratory syndrome virus (PRRSV) or porcine circovirus type 2 (PCV2) were studied and the profile of these subsets among these three infections was monitored. Germ-free piglets were used since their response could be directly correlated to the viral infection. Because SIV infections are resolved even by colostrum-deprived neonates whereas PRRSV and PCV2 infections are not, SIV was used as a benchmark for an effectively resolved viral infection. PRRSV caused a large increase in the proportion of lymphocytes at the site of infection and rapid differentiation of B cells leading to a high level of Ig-producing cells but asevere reduction in CD2(-)CD21(+) primed B cells. Unlike SIV and PCV2, PRRSV also caused an increase in terminally differentiated subset of CD2(+)CD8 alpha(+) gamma delta cells and polyclonal expansion of major V beta families suggesting

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP502%2F12%2F0110" target="_blank" >GAP502/12/0110: Úloha gamadelta T buněk při imunizaci naivního imunitního systému prasat</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinary Research

ISSN

0928-4249

e-ISSN

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Svazek periodika

45

Číslo periodika v rámci svazku

SEP 2014

Stát vydavatele periodika

FR - Francouzská republika

Počet stran výsledku

18

Strana od-do

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Kód UT WoS článku

000341317200001

EID výsledku v databázi Scopus

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