Manumycin A downregulates release of proinflammatory cytokines from TNF alpha stimulated human monocytes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00460046" target="_blank" >RIV/61388971:_____/16:00460046 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/16:00059635

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.imlet.2015.11.010" target="_blank" >http://dx.doi.org/10.1016/j.imlet.2015.11.010</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.imlet.2015.11.010" target="_blank" >10.1016/j.imlet.2015.11.010</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Manumycin A downregulates release of proinflammatory cytokines from TNF alpha stimulated human monocytes

Popis výsledku v původním jazyce

Macrolide antibiotics such as azithromycin or clarithromycin are known to have potent anti-inflammatory and immunomodulatory effects but these properties cannot be widely used due to a risk of bacterial resistance. We studied another polyketide antibiotic, structurally related manumycin A known as a streptomycete derived farnesyltransferase inhibitor with limited antibacterial effects, with respect to its potential regulation of mRNA expression of several genes associated with proinflammatory responses. Downregulation of mRNA for IL-6, TLR-8, IL-1 beta and IL-10 was found in THP-1 cells after 4 h stimulation with TNF alpha in the presence of manumycin A and downregulated TLR-8 and EGR-1 genes were observed after 8 h. Among the genes upregulated in response to manumycin were HMOX-1, TNFRSF10A, IL-1R1, TICAM2, NLRP12 after 4 h and only IL-1R1 after 8 h.

Název v anglickém jazyce

Manumycin A downregulates release of proinflammatory cytokines from TNF alpha stimulated human monocytes

Popis výsledku anglicky

Macrolide antibiotics such as azithromycin or clarithromycin are known to have potent anti-inflammatory and immunomodulatory effects but these properties cannot be widely used due to a risk of bacterial resistance. We studied another polyketide antibiotic, structurally related manumycin A known as a streptomycete derived farnesyltransferase inhibitor with limited antibacterial effects, with respect to its potential regulation of mRNA expression of several genes associated with proinflammatory responses. Downregulation of mRNA for IL-6, TLR-8, IL-1 beta and IL-10 was found in THP-1 cells after 4 h stimulation with TNF alpha in the presence of manumycin A and downregulated TLR-8 and EGR-1 genes were observed after 8 h. Among the genes upregulated in response to manumycin were HMOX-1, TNFRSF10A, IL-1R1, TICAM2, NLRP12 after 4 h and only IL-1R1 after 8 h.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Immunology Letters

ISSN

0165-2478

e-ISSN

—

Svazek periodika

169

Číslo periodika v rámci svazku

JAN 2016

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

8-14

Kód UT WoS článku

000369205200002

EID výsledku v databázi Scopus

2-s2.0-84947903541