The intestinal fatty acid-binding protein as a marker for intestinal damage in gastroschisis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F19%3A00504737" target="_blank" >RIV/61388971:_____/19:00504737 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/19:10394211 RIV/00064203:_____/19:10394211 RIV/68378041:_____/19:00579581

Výsledek na webu

<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210797" target="_blank" >https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210797</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0210797" target="_blank" >10.1371/journal.pone.0210797</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The intestinal fatty acid-binding protein as a marker for intestinal damage in gastroschisis

Popis výsledku v původním jazyce

Background/Purpose nWe analyzed the capacity of urinary Intestinal fatty acid-binding protein (I-FABP) to quantify the degree of mucosal injury in neonates with gastroschisis (GS) and to predict the speed of their clinical recovery after surgery. nMethods nIn this prospective study, we collected urine during the first 48h after surgery from neonates operated between 2012 and 2015 for GS. Neonates with surgery that did not include gut mucosa served as controls for simple GS and neonates with surgery for intestinal atresia served as control for complex GS patients. The I-FABP levels were analyzed by ELISA. nResults nUrinary I-FABP after the surgery is significantly higher in GS newborns than in control group, I-FABP in complex GS is higher than in simple GS. I-FABP can predict subsequent operation for ileus in patients with complex GS. Both ways of abdominal wall closure (i.e. primary closure and stepwise reconstruction) led to similar levels of I-FABP. None of the static I-FABP values was useful for the outcome prediction. The steep decrease in I-FABP after the surgery is associated with faster recovery, but it cannot predict early start of minimal enteral feeding, full enteral feeding or length of hospitalization. nConclusion nUrinary I-FABP reflects the mucosal damage in gastroschisis but it has only a limited predictive value for patients' outcome.nn

Název v anglickém jazyce

The intestinal fatty acid-binding protein as a marker for intestinal damage in gastroschisis

Popis výsledku anglicky

Background/Purpose nWe analyzed the capacity of urinary Intestinal fatty acid-binding protein (I-FABP) to quantify the degree of mucosal injury in neonates with gastroschisis (GS) and to predict the speed of their clinical recovery after surgery. nMethods nIn this prospective study, we collected urine during the first 48h after surgery from neonates operated between 2012 and 2015 for GS. Neonates with surgery that did not include gut mucosa served as controls for simple GS and neonates with surgery for intestinal atresia served as control for complex GS patients. The I-FABP levels were analyzed by ELISA. nResults nUrinary I-FABP after the surgery is significantly higher in GS newborns than in control group, I-FABP in complex GS is higher than in simple GS. I-FABP can predict subsequent operation for ileus in patients with complex GS. Both ways of abdominal wall closure (i.e. primary closure and stepwise reconstruction) led to similar levels of I-FABP. None of the static I-FABP values was useful for the outcome prediction. The steep decrease in I-FABP after the surgery is associated with faster recovery, but it cannot predict early start of minimal enteral feeding, full enteral feeding or length of hospitalization. nConclusion nUrinary I-FABP reflects the mucosal damage in gastroschisis but it has only a limited predictive value for patients' outcome.nn

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

<a href="/cs/project/NV15-28064A" target="_blank" >NV15-28064A: Imunologické biomarkery pro neinvazivní diagnostiku, volbu vhodné léčby a predikci komplikací idiopatických střevních zánětů</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLoS ONE

ISSN

1932-6203

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

e0210797

Kód UT WoS článku

000455808000049

EID výsledku v databázi Scopus

2-s2.0-85059963050