Update on Menopausal Hormone Therapy for Fracture Prevention

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F19%3A00531926" target="_blank" >RIV/61388971:_____/19:00531926 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/19:00538756

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s11914-019-00549-3" target="_blank" >https://link.springer.com/article/10.1007/s11914-019-00549-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11914-019-00549-3" target="_blank" >10.1007/s11914-019-00549-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Update on Menopausal Hormone Therapy for Fracture Prevention

Popis výsledku v původním jazyce

Purpose of Review The goal of the review is to assess the appropriateness of menopausal hormone therapy (MHT) for the primary prevention of bone loss in women at elevated risk in the early years after menopause. Recent Findings Estrogen alone or combined with progestin to protect the uterus from cancer significantly reduces the risk of osteoporosis-related fractures. MHT increases type 1 collagen production and osteoblast survival and maintains the equilibrium between bone resorption and bone formation by modulating osteoblast/osteocyte and T cell regulation of osteoclasts. Estrogens have positive effects on muscle and cartilage. Estrogen, but not antiresorptive therapies, can attenuate the inflammatory bone-microenvironment associated with estrogen deficiency. However, already on second year of administration, MHT is associated with excess breast cancer risk, increasing steadily with duration of use. MHT should be considered in women with premature estrogen deficiency and increased risk of bone loss and osteoporotic fractures. However, MHT use for the prevention of bone loss is hindered by increase in breast cancer risk even in women younger than 60 years old or who are within 10 years of menopause onset.

Název v anglickém jazyce

Update on Menopausal Hormone Therapy for Fracture Prevention

Popis výsledku anglicky

Purpose of Review The goal of the review is to assess the appropriateness of menopausal hormone therapy (MHT) for the primary prevention of bone loss in women at elevated risk in the early years after menopause. Recent Findings Estrogen alone or combined with progestin to protect the uterus from cancer significantly reduces the risk of osteoporosis-related fractures. MHT increases type 1 collagen production and osteoblast survival and maintains the equilibrium between bone resorption and bone formation by modulating osteoblast/osteocyte and T cell regulation of osteoclasts. Estrogens have positive effects on muscle and cartilage. Estrogen, but not antiresorptive therapies, can attenuate the inflammatory bone-microenvironment associated with estrogen deficiency. However, already on second year of administration, MHT is associated with excess breast cancer risk, increasing steadily with duration of use. MHT should be considered in women with premature estrogen deficiency and increased risk of bone loss and osteoporotic fractures. However, MHT use for the prevention of bone loss is hindered by increase in breast cancer risk even in women younger than 60 years old or who are within 10 years of menopause onset.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

<a href="/cs/project/NV18-05-00394" target="_blank" >NV18-05-00394: Studie vztahu mezi střevním mikrobiomem a zvýšeným rizikem chronických zánětlivých onemocnění pohybového aparátu, osteoporózy a revmatoidní artritidy</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Osteoporosis Reports

ISSN

1544-2241

e-ISSN

—

Svazek periodika

17

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

465-473

Kód UT WoS článku

000511749400011

EID výsledku v databázi Scopus

2-s2.0-85075404514