IN VIVO BIODOSIMETRY OF PORCINE T-LYMPHOCYTE SUBSETS AND NK CELLS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00524744" target="_blank" >RIV/61388971:_____/20:00524744 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/19:00537270

Výsledek na webu

<a href="https://academic.oup.com/rpd/article-abstract/186/2-3/181/5704036" target="_blank" >https://academic.oup.com/rpd/article-abstract/186/2-3/181/5704036</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/rpd/ncz199" target="_blank" >10.1093/rpd/ncz199</a>

Jazyk výsledku

angličtina

Název v původním jazyce

IN VIVO BIODOSIMETRY OF PORCINE T-LYMPHOCYTE SUBSETS AND NK CELLS

Popis výsledku v původním jazyce

The aim of the present study was to evaluate the biodosimetric potential of peripheral blood lymphocytes, particularly of T-cell subsets (null and T helper) and natural killer cells (NK), upon exposure to gamma irradiation (Co-60) in vivo. For this purpose, the change in relative numbers of NK cells and T-lymphocyte subsets, as well as in the H2AX phosphorylation rate, were evaluated as potential early markers of the lymphocytic response to irradiation in vivo. These experiments were performed on a Large White Pig model. As a result, significant but not dose-dependent changes in the proportion of lymphocyte subpopulations (NK cells, null and T helper cells) were found after exposure to ionising radiation in vivo. On the other hand, circulating NK cells showed relatively higher radioresistance capacity when compared to the T-lymphocyte subsets, however, gamma-H2AX expression showed no significant difference between the evaluated lymphocyte subsets.

Název v anglickém jazyce

IN VIVO BIODOSIMETRY OF PORCINE T-LYMPHOCYTE SUBSETS AND NK CELLS

Popis výsledku anglicky

The aim of the present study was to evaluate the biodosimetric potential of peripheral blood lymphocytes, particularly of T-cell subsets (null and T helper) and natural killer cells (NK), upon exposure to gamma irradiation (Co-60) in vivo. For this purpose, the change in relative numbers of NK cells and T-lymphocyte subsets, as well as in the H2AX phosphorylation rate, were evaluated as potential early markers of the lymphocytic response to irradiation in vivo. These experiments were performed on a Large White Pig model. As a result, significant but not dose-dependent changes in the proportion of lymphocyte subpopulations (NK cells, null and T helper cells) were found after exposure to ionising radiation in vivo. On the other hand, circulating NK cells showed relatively higher radioresistance capacity when compared to the T-lymphocyte subsets, however, gamma-H2AX expression showed no significant difference between the evaluated lymphocyte subsets.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Radiation Protection Dosimetry

ISSN

0144-8420

e-ISSN

—

Svazek periodika

186

Číslo periodika v rámci svazku

2-3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

181-185

Kód UT WoS článku

000530582200008

EID výsledku v databázi Scopus

2-s2.0-85082780217