BordetellaType III Secretion Injectosome and Effector Proteins

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00535324" target="_blank" >RIV/61388971:_____/20:00535324 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.frontiersin.org/articles/10.3389/fcimb.2020.00466/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fcimb.2020.00466/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fcimb.2020.00466" target="_blank" >10.3389/fcimb.2020.00466</a>

Jazyk výsledku

angličtina

Název v původním jazyce

BordetellaType III Secretion Injectosome and Effector Proteins

Popis výsledku v původním jazyce

Pertussis, also known as whooping cough, is a resurging acute respiratory disease of humans primarily caused by the Gram-negative coccobacilliBordetella pertussis, and less commonly by the human-adapted lineage ofB. parapertussis(HU). The ovine-adapted lineage ofB. parapertussis(OV)infects only sheep, whileB. bronchisepticacauses chronic and often asymptomatic respiratory infections in a broad range of mammals but rarely in humans. A largely overlapping set of virulence factors inflicts the pathogenicity of these bordetellae. Their genomes also harbor a pathogenicity island, namedbsclocus, that encodes components of the type III secretion injectosome, and adjacentbtrlocus with the type III regulatory proteins. The Bsc injectosome of bordetellae translocates the cytotoxic BteA effector protein, also referred to as BopC, into the cells of the mammalian hosts. While the role of type III secretion activity in the persistent colonization of the lower respiratory tract byB. bronchisepticais well recognized, the functionality of the type III secretion injectosome inB. pertussiswas overlooked for many years due to the adaptation of laboratory-passagedB. pertussisstrains. This review highlights the current knowledge of the type III secretion system in the so-called classicalBordetellaspecies, comprisingB. pertussis, B. parapertussis, andB. bronchiseptica, and discusses its functional divergence. Comparison with other well-studied bacterial injectosomes, regulation of the type III secretion on the transcriptional and post-transcriptional level, and activities of BteA effector protein and BopN protein, homologous to the type III secretion gatekeepers, are addressed.

Název v anglickém jazyce

BordetellaType III Secretion Injectosome and Effector Proteins

Popis výsledku anglicky

Pertussis, also known as whooping cough, is a resurging acute respiratory disease of humans primarily caused by the Gram-negative coccobacilliBordetella pertussis, and less commonly by the human-adapted lineage ofB. parapertussis(HU). The ovine-adapted lineage ofB. parapertussis(OV)infects only sheep, whileB. bronchisepticacauses chronic and often asymptomatic respiratory infections in a broad range of mammals but rarely in humans. A largely overlapping set of virulence factors inflicts the pathogenicity of these bordetellae. Their genomes also harbor a pathogenicity island, namedbsclocus, that encodes components of the type III secretion injectosome, and adjacentbtrlocus with the type III regulatory proteins. The Bsc injectosome of bordetellae translocates the cytotoxic BteA effector protein, also referred to as BopC, into the cells of the mammalian hosts. While the role of type III secretion activity in the persistent colonization of the lower respiratory tract byB. bronchisepticais well recognized, the functionality of the type III secretion injectosome inB. pertussiswas overlooked for many years due to the adaptation of laboratory-passagedB. pertussisstrains. This review highlights the current knowledge of the type III secretion system in the so-called classicalBordetellaspecies, comprisingB. pertussis, B. parapertussis, andB. bronchiseptica, and discusses its functional divergence. Comparison with other well-studied bacterial injectosomes, regulation of the type III secretion on the transcriptional and post-transcriptional level, and activities of BteA effector protein and BopN protein, homologous to the type III secretion gatekeepers, are addressed.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Cellular and Infection Microbiology

ISSN

2235-2988

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

SEP 4

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

17

Strana od-do

466

Kód UT WoS článku

000572210300001

EID výsledku v databázi Scopus

2-s2.0-85091247186