Spontaneous and Induced Tumors in Germ-Free Animals: A General Review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F21%3A00542584" target="_blank" >RIV/61388971:_____/21:00542584 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/21:10440289

Výsledek na webu

<a href="https://www.mdpi.com/1648-9144/57/3/260" target="_blank" >https://www.mdpi.com/1648-9144/57/3/260</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/medicina57030260" target="_blank" >10.3390/medicina57030260</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Spontaneous and Induced Tumors in Germ-Free Animals: A General Review

Popis výsledku v původním jazyce

Cancer, bacteria, and immunity relationships are much-debated topics in the last decade. Microbiome's importance for metabolic and immunologic modulation of the organism adaptation and responses has become progressively evident, and models to study these relationships, especially about carcinogenesis, have acquired primary importance. The availability of germ-free (GF) animals, i.e., animals born and maintained under completely sterile conditions avoiding the microbiome development offers a unique tool to investigate the role that bacteria can have in carcinogenesis and tumor development. The comparison between GF animals with the conventional (CV) counterpart with microbiome can help to evidence conditions and mechanisms directly involving bacterial activities in the modulation of carcinogenesis processes. Here, we review the literature about spontaneous cancer and cancer modeling in GF animals since the early studies, trying to offer a practical overview on the argument.

Název v anglickém jazyce

Spontaneous and Induced Tumors in Germ-Free Animals: A General Review

Popis výsledku anglicky

Cancer, bacteria, and immunity relationships are much-debated topics in the last decade. Microbiome's importance for metabolic and immunologic modulation of the organism adaptation and responses has become progressively evident, and models to study these relationships, especially about carcinogenesis, have acquired primary importance. The availability of germ-free (GF) animals, i.e., animals born and maintained under completely sterile conditions avoiding the microbiome development offers a unique tool to investigate the role that bacteria can have in carcinogenesis and tumor development. The comparison between GF animals with the conventional (CV) counterpart with microbiome can help to evidence conditions and mechanisms directly involving bacterial activities in the modulation of carcinogenesis processes. Here, we review the literature about spontaneous cancer and cancer modeling in GF animals since the early studies, trying to offer a practical overview on the argument.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Medicina-Lithuania

ISSN

1010-660X

e-ISSN

1648-9144

Svazek periodika

57

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

LT - Litevská republika

Počet stran výsledku

17

Strana od-do

260

Kód UT WoS článku

000633827600001

EID výsledku v databázi Scopus

2-s2.0-85103593898