Evaluation of estrogenic and antiestrogenic activity in sludge and explanation of individual compound contributions

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F22%3A00557651" target="_blank" >RIV/61388971:_____/22:00557651 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/22:10432572

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0304389421020768?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0304389421020768?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jhazmat.2021.127108" target="_blank" >10.1016/j.jhazmat.2021.127108</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation of estrogenic and antiestrogenic activity in sludge and explanation of individual compound contributions

Popis výsledku v původním jazyce

Mixture toxicity, including agonistic and antagonistic effects, is an unrevealed environmental problem. Estrogenic endocrine disruptors are known to cause adverse effects for aquatic biota, but causative chemicals and their contributions to the total activity in sewage sludge remain unknown. Therefore, advanced analytical methods, a yeast bioassay and mixture toxicity models were concurrently applied for the characterization of 8 selected sludges with delectable estrogenic activity (and 3 sludges with no activity as blanks) out of 25 samples from wastewater treatment plants (WWTPs). The first applied full logistic model adequately explained total activity by considering the concentrations of the monitored compounds. The results showed that the activity was primarily caused by natural estrogens in municipal WWTP sludge. Nevertheless, activity in a sample originating from a car wash facility was dominantly caused by partial agonists nonylphenols and only a model enabling prediction of all dose-response curve parameters of the final mixture curve explained these results. Antiestrogenic effects were negligible, and effect-directed analysis identified the causative chemicals.

Název v anglickém jazyce

Evaluation of estrogenic and antiestrogenic activity in sludge and explanation of individual compound contributions

Popis výsledku anglicky

Mixture toxicity, including agonistic and antagonistic effects, is an unrevealed environmental problem. Estrogenic endocrine disruptors are known to cause adverse effects for aquatic biota, but causative chemicals and their contributions to the total activity in sewage sludge remain unknown. Therefore, advanced analytical methods, a yeast bioassay and mixture toxicity models were concurrently applied for the characterization of 8 selected sludges with delectable estrogenic activity (and 3 sludges with no activity as blanks) out of 25 samples from wastewater treatment plants (WWTPs). The first applied full logistic model adequately explained total activity by considering the concentrations of the monitored compounds. The results showed that the activity was primarily caused by natural estrogens in municipal WWTP sludge. Nevertheless, activity in a sample originating from a car wash facility was dominantly caused by partial agonists nonylphenols and only a model enabling prediction of all dose-response curve parameters of the final mixture curve explained these results. Antiestrogenic effects were negligible, and effect-directed analysis identified the causative chemicals.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10511 - Environmental sciences (social aspects to be 5.7)

Projekt

<a href="/cs/project/SS02030008" target="_blank" >SS02030008: Centrum environmentálního výzkumu: Odpadové a oběhové hospodářství a environmentální bezpečnost</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Hazardous Materials

ISSN

0304-3894

e-ISSN

1873-3336

Svazek periodika

423

Číslo periodika v rámci svazku

FEB 5 2022

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

127108

Kód UT WoS článku

000696981500003

EID výsledku v databázi Scopus

2-s2.0-85114679051