Siderophores: a potential role as a diagnostic for invasive fungal disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F22%3A00564787" target="_blank" >RIV/61388971:_____/22:00564787 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/22:73615597

Výsledek na webu

<a href="https://journals.lww.com/co-infectiousdiseases/Abstract/2022/12000/Siderophores__a_potential_role_as_a_diagnostic_for.2.aspx" target="_blank" >https://journals.lww.com/co-infectiousdiseases/Abstract/2022/12000/Siderophores__a_potential_role_as_a_diagnostic_for.2.aspx</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/QCO.0000000000000862" target="_blank" >10.1097/QCO.0000000000000862</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Siderophores: a potential role as a diagnostic for invasive fungal disease

Popis výsledku v původním jazyce

Purpose of reviewInvasive fungal diseases (IFDs) such as invasive aspergillosis continue to be associated with high morbidity and mortality while presenting significant diagnostic challenges. Siderophores are high-affinity Fe3+ chelators produced by Aspergillus spp. and other fungi capable of causing IFD. Previously evaluated as a treatment target in mucormycosis, siderophores have recently emerged as new diagnostic targets for invasive aspergillosis and scedosporiosis. Here, we review the diagnostic potential of siderophores for diagnosing IFD, with a particular focus on invasive aspergillosis.Recent findingsThe major secreted siderophore of A. fumigatus, triacetylfusarinine C (TAFC), has been successfully detected by mass spectrometry in serum, BALF and urine of patients with invasive aspergillosis, with promising sensitivities and specificities in single-centre studies. Intracellular uptake of siderophores has also been utilized for imaging, wherein fungal siderophores have been conjugated with the easy-to-produce radioactive isotope gallium-68 (Ga-68) to visualize infected body sites in PET. For the Scedosporium apiospermum complex, another siderophore N(alpha)-methyl coprogen B has been shown promising as a marker for airway colonization in early studies.Siderophores and particular TAFC have the potential to revolutionize diagnostic pathways for invasive aspergillosis and other mould infections. However, larger multicentre studies are needed to confirm these promising performances. Methods that allow rapid and cost-effective measurements in routine clinical practice need to be developed, particularly when TAFC is used as a biomarker in patient specimens.

Název v anglickém jazyce

Siderophores: a potential role as a diagnostic for invasive fungal disease

Popis výsledku anglicky

Purpose of reviewInvasive fungal diseases (IFDs) such as invasive aspergillosis continue to be associated with high morbidity and mortality while presenting significant diagnostic challenges. Siderophores are high-affinity Fe3+ chelators produced by Aspergillus spp. and other fungi capable of causing IFD. Previously evaluated as a treatment target in mucormycosis, siderophores have recently emerged as new diagnostic targets for invasive aspergillosis and scedosporiosis. Here, we review the diagnostic potential of siderophores for diagnosing IFD, with a particular focus on invasive aspergillosis.Recent findingsThe major secreted siderophore of A. fumigatus, triacetylfusarinine C (TAFC), has been successfully detected by mass spectrometry in serum, BALF and urine of patients with invasive aspergillosis, with promising sensitivities and specificities in single-centre studies. Intracellular uptake of siderophores has also been utilized for imaging, wherein fungal siderophores have been conjugated with the easy-to-produce radioactive isotope gallium-68 (Ga-68) to visualize infected body sites in PET. For the Scedosporium apiospermum complex, another siderophore N(alpha)-methyl coprogen B has been shown promising as a marker for airway colonization in early studies.Siderophores and particular TAFC have the potential to revolutionize diagnostic pathways for invasive aspergillosis and other mould infections. However, larger multicentre studies are needed to confirm these promising performances. Methods that allow rapid and cost-effective measurements in routine clinical practice need to be developed, particularly when TAFC is used as a biomarker in patient specimens.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

<a href="/cs/project/GA21-17044S" target="_blank" >GA21-17044S: Infekční diagnostika příští generace</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Opinion in Infectious Diseases

ISSN

0951-7375

e-ISSN

1473-6527

Svazek periodika

35

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

485-492

Kód UT WoS článku

000883119300001

EID výsledku v databázi Scopus

2-s2.0-85141893280