Histopathological assessment of the microscopic activity in inflammatory bowel diseases: What are we looking for?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F22%3A00565406" target="_blank" >RIV/61388971:_____/22:00565406 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/22:00083461 RIV/00216208:11120/22:43924019 RIV/00064190:_____/22:N0000036

Výsledek na webu

<a href="https://www.wjgnet.com/1007-9327/full/v28/i36/5300.htm" target="_blank" >https://www.wjgnet.com/1007-9327/full/v28/i36/5300.htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3748/wjg.v28.i36.5300" target="_blank" >10.3748/wjg.v28.i36.5300</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Histopathological assessment of the microscopic activity in inflammatory bowel diseases: What are we looking for?

Popis výsledku v původním jazyce

Advances in diagnostics of inflammatory bowel diseases ( IBD) and improved treatment strategies allowed the establishment of new therapeutic endpoints. Currently, it is desirable not only to cease clinical symptoms, but mainly to achieve endoscopic remission, a macroscopic normalization of the bowel mucosa. However, up to one-third of IBD patients in remission exhibit persisting microscopic activity of the disease. The evidence suggests a better predictive value of histology for the development of clinical complications such as clinical relapse, surgical intervention, need for therapy escalation, or development of colorectal cancer. The proper assessment of microscopic inflammatory activity thus became an important part of the overall histopathological evaluation of colonic biopsies and many histopathological scoring indices have been established. Nonetheless, a majority of them have not been validated and no scoring index became a part of the routine bioptic practice. This review summarizes a predictive value of microscopic disease activity assessment for the subsequent clinical course of IBD, describes the most commonly used scoring indices for Crohn's disease and ulcerative colitis, and comments on current limitations and unresolved issues.

Název v anglickém jazyce

Histopathological assessment of the microscopic activity in inflammatory bowel diseases: What are we looking for?

Popis výsledku anglicky

Advances in diagnostics of inflammatory bowel diseases ( IBD) and improved treatment strategies allowed the establishment of new therapeutic endpoints. Currently, it is desirable not only to cease clinical symptoms, but mainly to achieve endoscopic remission, a macroscopic normalization of the bowel mucosa. However, up to one-third of IBD patients in remission exhibit persisting microscopic activity of the disease. The evidence suggests a better predictive value of histology for the development of clinical complications such as clinical relapse, surgical intervention, need for therapy escalation, or development of colorectal cancer. The proper assessment of microscopic inflammatory activity thus became an important part of the overall histopathological evaluation of colonic biopsies and many histopathological scoring indices have been established. Nonetheless, a majority of them have not been validated and no scoring index became a part of the routine bioptic practice. This review summarizes a predictive value of microscopic disease activity assessment for the subsequent clinical course of IBD, describes the most commonly used scoring indices for Crohn's disease and ulcerative colitis, and comments on current limitations and unresolved issues.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

World Journal of Gastroenterology

ISSN

1007-9327

e-ISSN

2219-2840

Svazek periodika

28

Číslo periodika v rámci svazku

36

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

5300-5312

Kód UT WoS článku

000891288400005

EID výsledku v databázi Scopus

2-s2.0-85139163983