Healthy Microbiome – A Mere Idea or a Sound Concept?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F22%3A00565865" target="_blank" >RIV/61388971:_____/22:00565865 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/22:00083548 RIV/00216224:14310/22:00128467

Výsledek na webu

<a href="https://www.biomed.cas.cz/physiolres/pdf/2022/71_719.pdf" target="_blank" >https://www.biomed.cas.cz/physiolres/pdf/2022/71_719.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33549/physiolres.934967" target="_blank" >10.33549/physiolres.934967</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Healthy Microbiome – A Mere Idea or a Sound Concept?

Popis výsledku v původním jazyce

Hundreds of studies in last decades have aimed to compare the microbiome of patients suffering from diverse diseases with that of healthy controls. The microbiome-related component was additionally identified in pathophysiology of many diseases formerly considered to depend only on the host physiology. This, however, opens important questions like: “What is the healthy microbiome?” or “Is it possible to define it unequivocally?”. In this review, we describe the main hindrances complicating the definition of “healthy microbiome” in terms of microbiota composition. We discuss the human microbiome from the perspective of classical ecology and we advocate for the shift from the stress on microbiota composition to the functions that microbiome ensures for the host. Finally, we propose to leave thenconcept of ideal healthy microbiome and replace it by focus on microbiome advantageous for the host, which always depends onnthe specific context like the age, genetics, dietary habits, bodynsite or physiological staten n

Název v anglickém jazyce

Healthy Microbiome – A Mere Idea or a Sound Concept?

Popis výsledku anglicky

Hundreds of studies in last decades have aimed to compare the microbiome of patients suffering from diverse diseases with that of healthy controls. The microbiome-related component was additionally identified in pathophysiology of many diseases formerly considered to depend only on the host physiology. This, however, opens important questions like: “What is the healthy microbiome?” or “Is it possible to define it unequivocally?”. In this review, we describe the main hindrances complicating the definition of “healthy microbiome” in terms of microbiota composition. We discuss the human microbiome from the perspective of classical ecology and we advocate for the shift from the stress on microbiota composition to the functions that microbiome ensures for the host. Finally, we propose to leave thenconcept of ideal healthy microbiome and replace it by focus on microbiome advantageous for the host, which always depends onnthe specific context like the age, genetics, dietary habits, bodynsite or physiological staten n

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

1802-9973

Svazek periodika

71

Číslo periodika v rámci svazku

NOV 25

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

20

Strana od-do

719-738

Kód UT WoS článku

000908339300001

EID výsledku v databázi Scopus

2-s2.0-85144636197