Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F22%3A00565986" target="_blank" >RIV/61388971:_____/22:00565986 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378050:_____/22:00565986 RIV/00216208:11110/22:10455224 RIV/00216208:11310/22:10455224

Výsledek na webu

<a href="https://www.frontiersin.org/articles/10.3389/fimmu.2022.1009198/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fimmu.2022.1009198/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fimmu.2022.1009198" target="_blank" >10.3389/fimmu.2022.1009198</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections

Popis výsledku v původním jazyce

Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, the relative differences in self-reactivity among individual T-cell clones were appreciated as important factors regulating their fate and immune response, but the role of self-reactivity in T-cell biology is incompletely understood. We addressed the role of self-reactivity in T-cell diversity by generating an atlas of mouse peripheral CD8(+) T cells, which revealed two unconventional populations of antigen-inexperienced T cells. In the next step, we examined the steady-state phenotype of monoclonal T cells with various levels of self-reactivity. Highly self-reactive clones preferentially differentiate into antigen-inexperienced memory-like cells, but do not form a population expressing type I interferon-induced genes, showing that these two subsets have unrelated origins. The functional comparison of naive monoclonal CD8(+) T cells specific to the identical model antigen did not show any correlation between the level of self-reactivity and the magnitude of the immune response.

Název v anglickém jazyce

Self-reactivity of CD8 T-cell clones determines their differentiation status rather than their responsiveness in infections

Popis výsledku anglicky

Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, the relative differences in self-reactivity among individual T-cell clones were appreciated as important factors regulating their fate and immune response, but the role of self-reactivity in T-cell biology is incompletely understood. We addressed the role of self-reactivity in T-cell diversity by generating an atlas of mouse peripheral CD8(+) T cells, which revealed two unconventional populations of antigen-inexperienced T cells. In the next step, we examined the steady-state phenotype of monoclonal T cells with various levels of self-reactivity. Highly self-reactive clones preferentially differentiate into antigen-inexperienced memory-like cells, but do not form a population expressing type I interferon-induced genes, showing that these two subsets have unrelated origins. The functional comparison of naive monoclonal CD8(+) T cells specific to the identical model antigen did not show any correlation between the level of self-reactivity and the magnitude of the immune response.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30102 - Immunology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Immunology

ISSN

1664-3224

e-ISSN

1664-3224

Svazek periodika

13

Číslo periodika v rámci svazku

6 Oct

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

14

Strana od-do

1009198

Kód UT WoS článku

000874521100001

EID výsledku v databázi Scopus

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