The gut-pancreas axis in type 1 diabetes a focus on environmental factors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F23%3A00575463" target="_blank" >RIV/61388971:_____/23:00575463 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1270297/full" target="_blank" >https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2023.1270297/full</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The gut-pancreas axis in type 1 diabetes a focus on environmental factors

Popis výsledku v původním jazyce

The global type 1 diabetes (T1D) incidence is rising too fast to be explained by genetic drift, thereby underlining the importance of environmental factors. Drawing further attention to environmental factors as being responsible for the rising T1D incidence is the reduced occurrence of high-risk haplotypes within the HLA genes in individuals developing T1D compared to previously (1). Several environmental factors have been associated with T1D, primarily from work on the non-obese diabetic (NOD) mouse model, and some of these factors, e.g. gluten (2) and enterovirus (3), have led to human intervention trials. Many of the proposed food and microbial environmental factors canntravel to the pancreatic islets from the intestinal lumen after crossing the intestinal barrier (4). In the pancreatic islets they are hypothesized to contribute to autoimmunity, e.g. via induction of beta-cell stress. Thus, the intestinal barrier function is likely of key importance. Noteworthy, intestinal permeability is increased both in pre- and clinical T1D (5), likely permitting luminal environmental factors easier entry. The present Research Topic gives an update on the involvement of environmental factors and the gut-pancreas axis in T1D.

Název v anglickém jazyce

The gut-pancreas axis in type 1 diabetes a focus on environmental factors

Popis výsledku anglicky

The global type 1 diabetes (T1D) incidence is rising too fast to be explained by genetic drift, thereby underlining the importance of environmental factors. Drawing further attention to environmental factors as being responsible for the rising T1D incidence is the reduced occurrence of high-risk haplotypes within the HLA genes in individuals developing T1D compared to previously (1). Several environmental factors have been associated with T1D, primarily from work on the non-obese diabetic (NOD) mouse model, and some of these factors, e.g. gluten (2) and enterovirus (3), have led to human intervention trials. Many of the proposed food and microbial environmental factors canntravel to the pancreatic islets from the intestinal lumen after crossing the intestinal barrier (4). In the pancreatic islets they are hypothesized to contribute to autoimmunity, e.g. via induction of beta-cell stress. Thus, the intestinal barrier function is likely of key importance. Noteworthy, intestinal permeability is increased both in pre- and clinical T1D (5), likely permitting luminal environmental factors easier entry. The present Research Topic gives an update on the involvement of environmental factors and the gut-pancreas axis in T1D.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30102 - Immunology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů