[68Ga]Ga-Ornibactin for Burkholderia cepacia complex Infection Imaging Using Positron Emission Tomography

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F23%3A00578119" target="_blank" >RIV/61388971:_____/23:00578119 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/23:10157991

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00469LX" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c00469LX</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.jmedchem.3c00469" target="_blank" >10.1021/acs.jmedchem.3c00469</a>

Jazyk výsledku

angličtina

Název v původním jazyce

[68Ga]Ga-Ornibactin for Burkholderia cepacia complex Infection Imaging Using Positron Emission Tomography

Popis výsledku v původním jazyce

Bacteria from the Burkholderia cepacia complex are generally consideredto be non-pathogenic to the healthypopulation. However, some of these species may cause serious nosocomialinfections in immunocompromised patients, as such, it is essentialto diagnose these infections rapidly so that adequate treatment canbe initiated. We report here the use of a radiolabeled siderophore,ornibactin (ORNB), for positron emission tomography imaging. We successfullyradiolabeled ORNB with gallium-68 with high radiochemical purity andproved that the resulting complex has optimal in vitro characteristics. In mice, the complex did not show excessive accumulationin organs and was excreted in the urine. We demonstrated that the[Ga-68]-Ga-ORNB complex accumulates at the site of Burkholderia multivorans infection, including pneumonia,in two animal infection models. These results suggest that [Ga-68]-Ga-ORNB is a promising tool for the diagnosis, monitoring, andevaluation of the therapeutic response to B. cepacia complex infection.

Název v anglickém jazyce

[68Ga]Ga-Ornibactin for Burkholderia cepacia complex Infection Imaging Using Positron Emission Tomography

Popis výsledku anglicky

Bacteria from the Burkholderia cepacia complex are generally consideredto be non-pathogenic to the healthypopulation. However, some of these species may cause serious nosocomialinfections in immunocompromised patients, as such, it is essentialto diagnose these infections rapidly so that adequate treatment canbe initiated. We report here the use of a radiolabeled siderophore,ornibactin (ORNB), for positron emission tomography imaging. We successfullyradiolabeled ORNB with gallium-68 with high radiochemical purity andproved that the resulting complex has optimal in vitro characteristics. In mice, the complex did not show excessive accumulationin organs and was excreted in the urine. We demonstrated that the[Ga-68]-Ga-ORNB complex accumulates at the site of Burkholderia multivorans infection, including pneumonia,in two animal infection models. These results suggest that [Ga-68]-Ga-ORNB is a promising tool for the diagnosis, monitoring, andevaluation of the therapeutic response to B. cepacia complex infection.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Medicinal Chemistry

ISSN

0022-2623

e-ISSN

1520-4804

Svazek periodika

66

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

7584-7593

Kód UT WoS článku

001004212000001

EID výsledku v databázi Scopus

2-s2.0-85163237048