Taxol is NOT produced sustainably by endophytic fungi ! – A case study for the damage that scientific papermills can cause for the scientific communities

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F24%3A00587066" target="_blank" >RIV/61388971:_____/24:00587066 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1749461324000125?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1749461324000125?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.fbr.2024.100367" target="_blank" >10.1016/j.fbr.2024.100367</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Taxol is NOT produced sustainably by endophytic fungi ! – A case study for the damage that scientific papermills can cause for the scientific communities

Popis výsledku v původním jazyce

Over three decades ago, the plant-derived anticancer agent taxol (brand name: paclitaxel) was reported from a fungal endophyte colonizing the producing plant. The hope that this finding could ever result in a sustainable production process has thus far been disappointed. Modern evidence on the evolution of secondary metabolites in plants vs. fungi suggests that this hypothesis (that fungi could produce such complex plant metabolites) is invalid. Still, numerous inconclusive original studiesand in particular, review papers by non-experts in the field-are continuously being published that claim the opposite. The current commentary tries to deal with the topic, taking the findings of –OMICS studies and current state-of-the art mycology into account. This can hopefully help to stop the scientific papermills from further spreading the fake news that fungi were capable of sustainable production of taxol.

Název v anglickém jazyce

Taxol is NOT produced sustainably by endophytic fungi ! – A case study for the damage that scientific papermills can cause for the scientific communities

Popis výsledku anglicky

Over three decades ago, the plant-derived anticancer agent taxol (brand name: paclitaxel) was reported from a fungal endophyte colonizing the producing plant. The hope that this finding could ever result in a sustainable production process has thus far been disappointed. Modern evidence on the evolution of secondary metabolites in plants vs. fungi suggests that this hypothesis (that fungi could produce such complex plant metabolites) is invalid. Still, numerous inconclusive original studiesand in particular, review papers by non-experts in the field-are continuously being published that claim the opposite. The current commentary tries to deal with the topic, taking the findings of –OMICS studies and current state-of-the art mycology into account. This can hopefully help to stop the scientific papermills from further spreading the fake news that fungi were capable of sustainable production of taxol.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

FUNGAL BIOLOGY REVIEWS

ISSN

1749-4613

e-ISSN

1878-0253

Svazek periodika

49

Číslo periodika v rámci svazku

September 24

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

4

Strana od-do

100367

Kód UT WoS článku

001238868200001

EID výsledku v databázi Scopus

2-s2.0-85192085281