Low-carbohydrate diet in children and young people with type 1 diabetes: A randomized controlled trial with cross-over design

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F24%3A00599717" target="_blank" >RIV/61388971:_____/24:00599717 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/24:10484139 RIV/00216208:11320/24:10484139 RIV/60460709:41210/24:98799 RIV/00064203:_____/24:10484139

Výsledek na webu

<a href="https://doi.org/10.1016/j.diabres.2024.111844" target="_blank" >https://doi.org/10.1016/j.diabres.2024.111844</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.diabres.2024.111844" target="_blank" >10.1016/j.diabres.2024.111844</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Low-carbohydrate diet in children and young people with type 1 diabetes: A randomized controlled trial with cross-over design

Popis výsledku v původním jazyce

Aims: We investigated whether a short period of tightly controlled low-carbohydrate diet (LCD) leads to higher time in range without increasing the associated risks in children and young people with diabetes (CYPwD). Methods: Thirty-five (CYPwD) were recruited into this randomized controlled cross-over study (20 female, 20 CSII, age 14.5 f 2.9 years, HbA1c 48.9 f 9.4 mmol/mol). The interventions were five and five weeks of readymade food box deliveries of isocaloric diets in random order: either LCD (94.5 f 4.7 g/day) or recommended carbohydrate diet (RCD) (191 f 19.2 g/day). The outcomes were continuous glucose monitoring parameters, anthropometric, laboratory and quality of life (QoL) data. Results: Time in range was significantly higher in the LCD than in the RCD period (77.1 % vs. 73.8 %, P=0.008). Times in hyperglycemia and average glycaemia were significantly lower in the LCD. There was no difference between the diets in time in hypoglycemia or glycemic variability. The subjects' body weight and BMI were significantly lower during the LCD. There was no significant difference in the LDL-cholesterol levels. No significant differences were observed in the self-assessed QoL. Conclusions: Short-term LCD led to an improvement of glycemic parameters without increasing time in hypoglycemia, disturbing the lipid profile or negatively affecting the quality of life of CYPwD.

Název v anglickém jazyce

Low-carbohydrate diet in children and young people with type 1 diabetes: A randomized controlled trial with cross-over design

Popis výsledku anglicky

Aims: We investigated whether a short period of tightly controlled low-carbohydrate diet (LCD) leads to higher time in range without increasing the associated risks in children and young people with diabetes (CYPwD). Methods: Thirty-five (CYPwD) were recruited into this randomized controlled cross-over study (20 female, 20 CSII, age 14.5 f 2.9 years, HbA1c 48.9 f 9.4 mmol/mol). The interventions were five and five weeks of readymade food box deliveries of isocaloric diets in random order: either LCD (94.5 f 4.7 g/day) or recommended carbohydrate diet (RCD) (191 f 19.2 g/day). The outcomes were continuous glucose monitoring parameters, anthropometric, laboratory and quality of life (QoL) data. Results: Time in range was significantly higher in the LCD than in the RCD period (77.1 % vs. 73.8 %, P=0.008). Times in hyperglycemia and average glycaemia were significantly lower in the LCD. There was no difference between the diets in time in hypoglycemia or glycemic variability. The subjects' body weight and BMI were significantly lower during the LCD. There was no significant difference in the LDL-cholesterol levels. No significant differences were observed in the self-assessed QoL. Conclusions: Short-term LCD led to an improvement of glycemic parameters without increasing time in hypoglycemia, disturbing the lipid profile or negatively affecting the quality of life of CYPwD.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

<a href="/cs/project/NU21-01-00085" target="_blank" >NU21-01-00085: Vliv nízkosacharidové diety na kontrolu diabetu 1. typu a rozvoj ostrůvkové autoimunity</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Diabetes Research and Clinical Practice

ISSN

0168-8227

e-ISSN

1872-8227

Svazek periodika

217

Číslo periodika v rámci svazku

November

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

111844

Kód UT WoS článku

001311545700001

EID výsledku v databázi Scopus

2-s2.0-85203064321