ELIMAIA-ELIMED: a new user platform for radiobiological research utilizing laser-driven protons

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F25%3A00619782" target="_blank" >RIV/61388971:_____/25:00619782 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389005:_____/25:00619782 RIV/10974938:_____/25:25_87_06

Výsledek na webu

<a href="https://www.frontiersin.org/journals/physics/articles/10.3389/fphy.2025.1567622" target="_blank" >https://www.frontiersin.org/journals/physics/articles/10.3389/fphy.2025.1567622</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fphy.2025.1567622" target="_blank" >10.3389/fphy.2025.1567622</a>

Jazyk výsledku

angličtina

Název v původním jazyce

ELIMAIA-ELIMED: a new user platform for radiobiological research utilizing laser-driven protons

Popis výsledku v původním jazyce

The ELIMAIA-ELIMED beamline, powered by the L3 HAPLS petawatt laser, enables the irradiation of biological samples with intermediate-energy laser-driven protons (LDP) in a multi-shot regime. In the pilot radiobiological experiment, protons with a mean energy of similar to 24 MeV and doses up to similar to 14 mGy per shot, with similar to 4 ns bunch duration, were used to irradiate AG01522 normal human skin fibroblasts. The shortest irradiation time achieved was down to similar to 17 min/Gy, while the mean and peak dose rates reached similar to 1 x 10-3 and 3.5 x 106 Gy/s, respectively. The cells were exposed to doses ranging from similar to 0.4 to 1.5 Gy and analyzed for DNA damage, with double-strand breaks visualized as 53BP1 foci. Despite the differences in shot exposures between the multi-shot LDP and the previous experiments (at other facility) with single-shot LDP, similar DNA damage responses were observed. Results with conventionally accelerated protons align closely with the corresponding single-shot LDP samples. These experimental results were achieved as part of the flagship experiment FLAIM (within the IMPULSE EU-funded project) and serve as an initial demonstration of the ELIMAIA-ELIMED platform's potential for advanced radiobiological research, creating new opportunities for such studies utilizing laser-driven ion sources.

Název v anglickém jazyce

ELIMAIA-ELIMED: a new user platform for radiobiological research utilizing laser-driven protons

Popis výsledku anglicky

The ELIMAIA-ELIMED beamline, powered by the L3 HAPLS petawatt laser, enables the irradiation of biological samples with intermediate-energy laser-driven protons (LDP) in a multi-shot regime. In the pilot radiobiological experiment, protons with a mean energy of similar to 24 MeV and doses up to similar to 14 mGy per shot, with similar to 4 ns bunch duration, were used to irradiate AG01522 normal human skin fibroblasts. The shortest irradiation time achieved was down to similar to 17 min/Gy, while the mean and peak dose rates reached similar to 1 x 10-3 and 3.5 x 106 Gy/s, respectively. The cells were exposed to doses ranging from similar to 0.4 to 1.5 Gy and analyzed for DNA damage, with double-strand breaks visualized as 53BP1 foci. Despite the differences in shot exposures between the multi-shot LDP and the previous experiments (at other facility) with single-shot LDP, similar DNA damage responses were observed. Results with conventionally accelerated protons align closely with the corresponding single-shot LDP samples. These experimental results were achieved as part of the flagship experiment FLAIM (within the IMPULSE EU-funded project) and serve as an initial demonstration of the ELIMAIA-ELIMED platform's potential for advanced radiobiological research, creating new opportunities for such studies utilizing laser-driven ion sources.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Physics

ISSN

2296-424X

e-ISSN

2296-424X

Svazek periodika

13

Číslo periodika v rámci svazku

April

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

10

Strana od-do

1567622

Kód UT WoS článku

001481850700001

EID výsledku v databázi Scopus

2-s2.0-105004417179