From ultrafast laser-generated radiation to clinical impact: a roadmap for radiobiology and cancer research at the extreme light infrastructure (ELI)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F25%3A00637983" target="_blank" >RIV/61388971:_____/25:00637983 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389005:_____/25:00637983 RIV/10974938:_____/25:25_96_01

Výsledek na webu

<a href="https://link.springer.com/article/10.1140/epjp/s13360-025-06662-w" target="_blank" >https://link.springer.com/article/10.1140/epjp/s13360-025-06662-w</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1140/epjp/s13360-025-06662-w" target="_blank" >10.1140/epjp/s13360-025-06662-w</a>

Jazyk výsledku

angličtina

Název v původním jazyce

From ultrafast laser-generated radiation to clinical impact: a roadmap for radiobiology and cancer research at the extreme light infrastructure (ELI)

Popis výsledku v původním jazyce

The extreme light infrastructure (ELI) is emerging as a state-of-the-art facility providing international users with open access to ultrashort laser-driven particle bunches, ranging from a few femtoseconds to a few nanoseconds, for advanced radiobiology studies. ELI offers femtosecond-class laser pulses and ultrafast ionizing radiation characterized by extremely high instantaneous dose rates (107-1012 Gy/s). The versatility of ELI's cutting-edge technologies enables the generation of high repetition rate (1 Hz-1 kHz) secondary sources (protons, ions, electrons, and neutrons) with energies from a few MeV to several hundred MeV, achieved over sub-millimetre to millimetre-scale acceleration lengths, along with fundamental research in the field of ultrahigh intensity laser-matter interaction based on the use of the highest peak power laser pulses available worldwide. Harnessing these laser-driven particle sources for radiobiology and medical research demands a coordinated international effort, with a strong focus on advancing scientific instrumentation and refining experimental methodologies to support progress in ultrafast laser-driven radiation biology. This roadmap underscores the need for systematically designed experiments across ELI facilities, supported by preparatory research at users' home laboratories, alongside the ongoing development of instrumentation and infrastructure. These efforts are critical to rigorously assess and validate the therapeutic potential of these novel sources, paving the way for a transformative shift in radiation biology and medicine.

Název v anglickém jazyce

From ultrafast laser-generated radiation to clinical impact: a roadmap for radiobiology and cancer research at the extreme light infrastructure (ELI)

Popis výsledku anglicky

The extreme light infrastructure (ELI) is emerging as a state-of-the-art facility providing international users with open access to ultrashort laser-driven particle bunches, ranging from a few femtoseconds to a few nanoseconds, for advanced radiobiology studies. ELI offers femtosecond-class laser pulses and ultrafast ionizing radiation characterized by extremely high instantaneous dose rates (107-1012 Gy/s). The versatility of ELI's cutting-edge technologies enables the generation of high repetition rate (1 Hz-1 kHz) secondary sources (protons, ions, electrons, and neutrons) with energies from a few MeV to several hundred MeV, achieved over sub-millimetre to millimetre-scale acceleration lengths, along with fundamental research in the field of ultrahigh intensity laser-matter interaction based on the use of the highest peak power laser pulses available worldwide. Harnessing these laser-driven particle sources for radiobiology and medical research demands a coordinated international effort, with a strong focus on advancing scientific instrumentation and refining experimental methodologies to support progress in ultrafast laser-driven radiation biology. This roadmap underscores the need for systematically designed experiments across ELI facilities, supported by preparatory research at users' home laboratories, alongside the ongoing development of instrumentation and infrastructure. These efforts are critical to rigorously assess and validate the therapeutic potential of these novel sources, paving the way for a transformative shift in radiation biology and medicine.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Physical Journal Plus

ISSN

2190-5444

e-ISSN

2190-5444

Svazek periodika

140

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

11

Strana od-do

730

Kód UT WoS článku

001543673700002

EID výsledku v databázi Scopus

2-s2.0-105012444111