A new possible way of anthracycline cytostatics decontamination

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F17%3A00475066" target="_blank" >RIV/61388980:_____/17:00475066 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389013:_____/17:00475066 RIV/00216208:11110/17:10363933

Výsledek na webu

<a href="http://dx.doi.org/10.1039/c6nj03051c" target="_blank" >http://dx.doi.org/10.1039/c6nj03051c</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c6nj03051c" target="_blank" >10.1039/c6nj03051c</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A new possible way of anthracycline cytostatics decontamination

Popis výsledku v původním jazyce

The widespread use of cytotoxic drugs in the treatment of cancer has led to the production of large amounts of contaminated wastes with high exposure risk of medical staff handling cytostatics. For this reason it is essential to use a highly effective and fast decontaminating agent for the decontamination process. Currently used decontamination agents based on NaOCl and NaOH are not sufficient according to our results and also according to literature data. Therefore we have developed a new decontamination agent based on titania nanoparticles, which appears to be a very efficient and fast decontamination agent according to our research data. Anthracycline antibiotics are valuable and frequently used drugs in various chemotherapeutic schemes. They have high efficacy, but also high toxicity, e.g. myelosuppression and cardiotoxicity. They can also act as vesicants in the case of extravasation. Due to their mechanism of action, anthracycline antibiotics have mutagenic and carcinogenic effects. Long term contact, even with a trace amount, can cause changes in human health. Safe decontamination of cytotoxic drug contaminated areas with an agent, which can cause degradation to non-toxic products, is essential. High sorption ability of doxorubicin and epirubicin to titania predisposes TiO2 to become a new, effective and inexpensive agent for area decontamination and degradation of anthracycline antibiotics.

Název v anglickém jazyce

A new possible way of anthracycline cytostatics decontamination

Popis výsledku anglicky

The widespread use of cytotoxic drugs in the treatment of cancer has led to the production of large amounts of contaminated wastes with high exposure risk of medical staff handling cytostatics. For this reason it is essential to use a highly effective and fast decontaminating agent for the decontamination process. Currently used decontamination agents based on NaOCl and NaOH are not sufficient according to our results and also according to literature data. Therefore we have developed a new decontamination agent based on titania nanoparticles, which appears to be a very efficient and fast decontamination agent according to our research data. Anthracycline antibiotics are valuable and frequently used drugs in various chemotherapeutic schemes. They have high efficacy, but also high toxicity, e.g. myelosuppression and cardiotoxicity. They can also act as vesicants in the case of extravasation. Due to their mechanism of action, anthracycline antibiotics have mutagenic and carcinogenic effects. Long term contact, even with a trace amount, can cause changes in human health. Safe decontamination of cytotoxic drug contaminated areas with an agent, which can cause degradation to non-toxic products, is essential. High sorption ability of doxorubicin and epirubicin to titania predisposes TiO2 to become a new, effective and inexpensive agent for area decontamination and degradation of anthracycline antibiotics.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

New Journal of Chemistry

ISSN

1144-0546

e-ISSN

—

Svazek periodika

41

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

3975-3985

Kód UT WoS článku

000401533200033

EID výsledku v databázi Scopus

2-s2.0-85022092526