Singlet Oxygen Production and Biological Activity of Hexanuclear Chalcocyanide Rhenium Cluster Complexes [{Re(6)Q(8)}(CN)(6)](4-) (Q = S, Se, Te)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F17%3A00480254" target="_blank" >RIV/61388980:_____/17:00480254 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388955:_____/17:00480254

Výsledek na webu

<a href="http://dx.doi.org/10.1021/acs.inorgchem.7b02212" target="_blank" >http://dx.doi.org/10.1021/acs.inorgchem.7b02212</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.inorgchem.7b02212" target="_blank" >10.1021/acs.inorgchem.7b02212</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Singlet Oxygen Production and Biological Activity of Hexanuclear Chalcocyanide Rhenium Cluster Complexes [{Re(6)Q(8)}(CN)(6)](4-) (Q = S, Se, Te)

Popis výsledku v původním jazyce

Octahedral rhenium cluster complexes have recently emerged as relevant building blocks for the design of singlet oxygen photosensitizing materials toward biological applications such as blue-light photodynamic therapy. However, their singlet oxygen generation ability as well as biological properties have been studied only superficially. Herein we investigate in detail the singlet oxygen photogeneration, dark and photoinduced cytotoxicity, cellular uptake kinetics, cellular localization and in vitro photoinduced oxidative stress, and photodynamic cytotoxicity of the series of octahedral rhenium cluster complexes [{Re(6)Q(2)}(CN)(6)](4-) where Q = S, Se, Te. Our results demonstrate that the selenium-containing complex possesses optimal properties in terms of absorption and singlet oxygen productivity. These features coupled with the cellular internalization and low dark toxicity lead to the first photoinduced cytotoxic effect observed for a molecular [{M(6)Q(8)}L-6] complex, making it a promising object for further study in terms of blue-light PDT.

Název v anglickém jazyce

Singlet Oxygen Production and Biological Activity of Hexanuclear Chalcocyanide Rhenium Cluster Complexes [{Re(6)Q(8)}(CN)(6)](4-) (Q = S, Se, Te)

Popis výsledku anglicky

Octahedral rhenium cluster complexes have recently emerged as relevant building blocks for the design of singlet oxygen photosensitizing materials toward biological applications such as blue-light photodynamic therapy. However, their singlet oxygen generation ability as well as biological properties have been studied only superficially. Herein we investigate in detail the singlet oxygen photogeneration, dark and photoinduced cytotoxicity, cellular uptake kinetics, cellular localization and in vitro photoinduced oxidative stress, and photodynamic cytotoxicity of the series of octahedral rhenium cluster complexes [{Re(6)Q(2)}(CN)(6)](4-) where Q = S, Se, Te. Our results demonstrate that the selenium-containing complex possesses optimal properties in terms of absorption and singlet oxygen productivity. These features coupled with the cellular internalization and low dark toxicity lead to the first photoinduced cytotoxic effect observed for a molecular [{M(6)Q(8)}L-6] complex, making it a promising object for further study in terms of blue-light PDT.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

<a href="/cs/project/GA16-15020S" target="_blank" >GA16-15020S: Fotoaktivní polymerní materiály s nanostrukturovanými povrchy pro biomedicínské aplikace</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Inorganic Chemistry

ISSN

0020-1669

e-ISSN

—

Svazek periodika

56

Číslo periodika v rámci svazku

21

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

13491-13499

Kód UT WoS článku

000414820100089

EID výsledku v databázi Scopus

2-s2.0-85033408326