Host-Guest Chemistry of Carboranes: Synthesis of Carboxylate Derivatives and Their Binding to Cyclodextrins

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F18%3A00493265" target="_blank" >RIV/61388980:_____/18:00493265 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/18:10375970

Výsledek na webu

<a href="http://dx.doi.org/10.1002/chem.201802134" target="_blank" >http://dx.doi.org/10.1002/chem.201802134</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/chem.201802134" target="_blank" >10.1002/chem.201802134</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Host-Guest Chemistry of Carboranes: Synthesis of Carboxylate Derivatives and Their Binding to Cyclodextrins

Popis výsledku v původním jazyce

Polyhedral carboxymethyl carborane (C2B10H12) derivatives, including mono- and disubstituted o-, m-, and p-isomers, have been synthesized. Supramolecular host-guest complexation of these derivatives with cyclodextrins (CDs, namely, alpha-, beta-, and gamma-CD) has been investigated in water. The globular structure of the carborane binding moiety and its hydrophobic character qualify it as an ideal recognition site to form stable inclusion complexes with macrocyclic host molecules in aqueous solution. The measured binding affinities for the carborane derivatives were in the millimolar range (K-a=10(3)-10(4)m(-1)) with differently sized CDs, and preferential binding to beta-CD.

Název v anglickém jazyce

Host-Guest Chemistry of Carboranes: Synthesis of Carboxylate Derivatives and Their Binding to Cyclodextrins

Popis výsledku anglicky

Polyhedral carboxymethyl carborane (C2B10H12) derivatives, including mono- and disubstituted o-, m-, and p-isomers, have been synthesized. Supramolecular host-guest complexation of these derivatives with cyclodextrins (CDs, namely, alpha-, beta-, and gamma-CD) has been investigated in water. The globular structure of the carborane binding moiety and its hydrophobic character qualify it as an ideal recognition site to form stable inclusion complexes with macrocyclic host molecules in aqueous solution. The measured binding affinities for the carborane derivatives were in the millimolar range (K-a=10(3)-10(4)m(-1)) with differently sized CDs, and preferential binding to beta-CD.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemistry - A European Journal

ISSN

0947-6539

e-ISSN

—

Svazek periodika

24

Číslo periodika v rámci svazku

49

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

12970-12975

Kód UT WoS článku

000443382500028

EID výsledku v databázi Scopus

2-s2.0-85052611031