Phosphinate Apical Ligands: A Route to a Water-Stable Octahedral Molybdenum Cluster Complex

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F19%3A00517993" target="_blank" >RIV/61388980:_____/19:00517993 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22330/19:43919484

Výsledek na webu

<a href="https://pubs.acs.org/doi/10.1021/acs.inorgchem.9b02569" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.inorgchem.9b02569</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.inorgchem.9b02569" target="_blank" >10.1021/acs.inorgchem.9b02569</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Phosphinate Apical Ligands: A Route to a Water-Stable Octahedral Molybdenum Cluster Complex

Popis výsledku v původním jazyce

Recent studies have unraveled the potential of octahedral molybdenum cluster complexes (Mo6) as relevant red phosphors and photosensitizers of singlet oxygen, O2(1Δg), for photobiological applications. However, these complexes tend to hydrolyze in an aqueous environment, which deteriorates their properties and limits their applications. To address this issue, we show that phenylphosphinates are extraordinary apical ligands for the construction of Mo6 complexes. These new complexes display unmatched luminescence quantum yields and singlet oxygen production in aqueous solutions. More importantly, the complex with diphenylphosphinate ligands is the only stable complex of these types in aqueous media. These complexes internalize in lysosomes of HeLa cells, have no dark toxicity, and yet are phototoxic in the submicromolar concentration range. The superior hydrolytic stability of the diphenylphosphinate complex allows for conservation of its photophysical properties and biological activity over a long period, making it a promising compound for photobiological applications.

Název v anglickém jazyce

Phosphinate Apical Ligands: A Route to a Water-Stable Octahedral Molybdenum Cluster Complex

Popis výsledku anglicky

Recent studies have unraveled the potential of octahedral molybdenum cluster complexes (Mo6) as relevant red phosphors and photosensitizers of singlet oxygen, O2(1Δg), for photobiological applications. However, these complexes tend to hydrolyze in an aqueous environment, which deteriorates their properties and limits their applications. To address this issue, we show that phenylphosphinates are extraordinary apical ligands for the construction of Mo6 complexes. These new complexes display unmatched luminescence quantum yields and singlet oxygen production in aqueous solutions. More importantly, the complex with diphenylphosphinate ligands is the only stable complex of these types in aqueous media. These complexes internalize in lysosomes of HeLa cells, have no dark toxicity, and yet are phototoxic in the submicromolar concentration range. The superior hydrolytic stability of the diphenylphosphinate complex allows for conservation of its photophysical properties and biological activity over a long period, making it a promising compound for photobiological applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Inorganic Chemistry

ISSN

0020-1669

e-ISSN

—

Svazek periodika

58

Číslo periodika v rámci svazku

24

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

16546-16552

Kód UT WoS článku

000503330800025

EID výsledku v databázi Scopus

2-s2.0-85076272314