How the surface chemical properties of nanoceria are related to its enzyme-like, antiviral and degradation activity

Kód výsledku v IS VaVaI

RIV/61388980:_____/22:00560142 - isvavai.cz

Nalezeny alternativní kódy

RIV/44555601:13440/22:43897019 RIV/44555601:13520/22:43897019 RIV/29372259:_____/22:N0000027

Výsledek na webu

https://doi.org/10.1039/D2EN00173J

DOI - Digital Object Identifier

10.1039/d2en00173j

Jazyk výsledku

angličtina

Název v původním jazyce

How the surface chemical properties of nanoceria are related to its enzyme-like, antiviral and degradation activity

Popis výsledku v původním jazyce

Five different water-based precipitation methods have been used to prepare nanoceria with significantly different redox and acid/base properties, which have been described in detail by a number of analytical methods. Differences in particle size, morphology, porosity, but especially in defect structure and in the surface chemical composition of nanoceria had a crucial impact on their reactivity in several environmentally and biologically oriented model reactions. Ceria-catalyzed hydrolysis of two phosphodiester biomolecules (p-NPPC and p-NP-TMP) revealed high phospholipase C and D mimetic activity of all tested materials. On the other hand, the efficiency in degradation of toxic organophosphates (methyl parathion/oxon, agent VX, GD) is highly dependent on the solvent used (water or acetonitrile). Water slows down the degradation rate, but has a strikingly different effect on each ceria sample, which is related to the ceria surface structure and its interaction with the model compound and/or water. Two materials with a significant number of defects and oxygen-containing surface groups also showed highly virucidal properties against enveloped (adenovirus 5) and non-enveloped (human herpes simplex) viruses while having very low cytotoxicity.

Název v anglickém jazyce

How the surface chemical properties of nanoceria are related to its enzyme-like, antiviral and degradation activity

Popis výsledku anglicky

Five different water-based precipitation methods have been used to prepare nanoceria with significantly different redox and acid/base properties, which have been described in detail by a number of analytical methods. Differences in particle size, morphology, porosity, but especially in defect structure and in the surface chemical composition of nanoceria had a crucial impact on their reactivity in several environmentally and biologically oriented model reactions. Ceria-catalyzed hydrolysis of two phosphodiester biomolecules (p-NPPC and p-NP-TMP) revealed high phospholipase C and D mimetic activity of all tested materials. On the other hand, the efficiency in degradation of toxic organophosphates (methyl parathion/oxon, agent VX, GD) is highly dependent on the solvent used (water or acetonitrile). Water slows down the degradation rate, but has a strikingly different effect on each ceria sample, which is related to the ceria surface structure and its interaction with the model compound and/or water. Two materials with a significant number of defects and oxygen-containing surface groups also showed highly virucidal properties against enveloped (adenovirus 5) and non-enveloped (human herpes simplex) viruses while having very low cytotoxicity.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Science-Nano

ISSN

2051-8153

e-ISSN

2051-8161

Svazek periodika

9

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

17

Strana od-do

3485-3501

Kód UT WoS článku

000837388400001

EID výsledku v databázi Scopus

2-s2.0-85135588460