Low-dimensional compounds containing bioactive ligands. nPart XX: crystal structures, cytotoxic, antimicrobial activities and DNA/BSA binding of oligonuclear zinc complexes with halogen derivatives of 8-hydroxyquinoline

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F23%3A00570239" target="_blank" >RIV/61388980:_____/23:00570239 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378271:_____/23:00570239

Výsledek na webu

<a href="https://hdl.handle.net/11104/0342052" target="_blank" >https://hdl.handle.net/11104/0342052</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/inorganics11020060" target="_blank" >10.3390/inorganics11020060</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Low-dimensional compounds containing bioactive ligands. nPart XX: crystal structures, cytotoxic, antimicrobial activities and DNA/BSA binding of oligonuclear zinc complexes with halogen derivatives of 8-hydroxyquinoline

Popis výsledku v původním jazyce

Two tetranuclear [Zn4Cl2(ClQ)6]2DMF and [Zn4Cl2(ClQ)6(H2O)2]4DMF, as well as three dinuclear [Zn2(ClQ)3(HClQ)3]I3, [Zn2(dClQ)2(H2O)6(SO4)] and [Zn2(dBrQ)2(H2O)6(SO4)], complexes (HClQ = 5-chloro-8-hydroxyquinoline, HdClQ = 5,7-dichloro-8-hydroxyquinoline and HdBrQ = 5,7-dibromo-8-hydroxyquinoline) were prepared as possible anticancer or antimicrobial agents and characterized by IR spectroscopy, elemental analysis and single crystal X-ray structure analysis. The stability of the complexes in solution was verified by NMR spectroscopy. Antiproliferative activity and selectivity of the prepared com plexes were studied using in vitro MTT assay against the HeLa, A549, MCF-7, MDA-MB-231, HCT116 and Caco-2 cancer cell lines and on the Cos-7 non-cancerous cell line.

Název v anglickém jazyce

Low-dimensional compounds containing bioactive ligands. nPart XX: crystal structures, cytotoxic, antimicrobial activities and DNA/BSA binding of oligonuclear zinc complexes with halogen derivatives of 8-hydroxyquinoline

Popis výsledku anglicky

Two tetranuclear [Zn4Cl2(ClQ)6]2DMF and [Zn4Cl2(ClQ)6(H2O)2]4DMF, as well as three dinuclear [Zn2(ClQ)3(HClQ)3]I3, [Zn2(dClQ)2(H2O)6(SO4)] and [Zn2(dBrQ)2(H2O)6(SO4)], complexes (HClQ = 5-chloro-8-hydroxyquinoline, HdClQ = 5,7-dichloro-8-hydroxyquinoline and HdBrQ = 5,7-dibromo-8-hydroxyquinoline) were prepared as possible anticancer or antimicrobial agents and characterized by IR spectroscopy, elemental analysis and single crystal X-ray structure analysis. The stability of the complexes in solution was verified by NMR spectroscopy. Antiproliferative activity and selectivity of the prepared com plexes were studied using in vitro MTT assay against the HeLa, A549, MCF-7, MDA-MB-231, HCT116 and Caco-2 cancer cell lines and on the Cos-7 non-cancerous cell line.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Inorganic

ISSN

2304-6740

e-ISSN

2304-6740

Svazek periodika

11

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

24

Strana od-do

60

Kód UT WoS článku

000939265300001

EID výsledku v databázi Scopus

2-s2.0-85148747858