Effect of Ca2+ Efflux Pathway Distribution and Exogenous Ca2+ Buffers on Intracellular Ca2+ Dynamics in the Rat Ventricular Myocyte: A Simulation Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388998%3A_____%2F14%3A00430874" target="_blank" >RIV/61388998:_____/14:00430874 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/14:00080146

Výsledek na webu

<a href="http://dx.doi.org/10.1155/2014/920208" target="_blank" >http://dx.doi.org/10.1155/2014/920208</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2014/920208" target="_blank" >10.1155/2014/920208</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of Ca2+ Efflux Pathway Distribution and Exogenous Ca2+ Buffers on Intracellular Ca2+ Dynamics in the Rat Ventricular Myocyte: A Simulation Study

Popis výsledku v původním jazyce

We have used a previously published computer model of the rat cardiac ventricular myocyte to investigate the effect of changing the distribution of Ca efflux pathways (SERCA, Na/Ca exchange, and sarcolemmal Ca ATPase) between the dyad and bulk cytoplasmand the effect of adding exogenous Ca buffers (BAPTA or EGTA), which are used experimentally to differentially buffer Ca in the dyad and bulk cytoplasm, on cellular Ca cycling. Increasing the dyadic fraction of a particular Ca efflux pathway increases the amount of Ca removed by that pathway, with corresponding changes in Ca efflux from the bulk cytoplasm. The magnitude of these effects varies with the proportion of the total Ca removed from the cytoplasm by that pathway. Differences in the response toEGTA and BAPTA, including changes in Ca-dependent inactivation of the L-type Ca current, resulted from the buffers acting as slow and fast ?shuttles, respectively, removing Ca from the dyadic space. The data suggest that complex changes i

Název v anglickém jazyce

Effect of Ca2+ Efflux Pathway Distribution and Exogenous Ca2+ Buffers on Intracellular Ca2+ Dynamics in the Rat Ventricular Myocyte: A Simulation Study

Popis výsledku anglicky

We have used a previously published computer model of the rat cardiac ventricular myocyte to investigate the effect of changing the distribution of Ca efflux pathways (SERCA, Na/Ca exchange, and sarcolemmal Ca ATPase) between the dyad and bulk cytoplasmand the effect of adding exogenous Ca buffers (BAPTA or EGTA), which are used experimentally to differentially buffer Ca in the dyad and bulk cytoplasm, on cellular Ca cycling. Increasing the dyadic fraction of a particular Ca efflux pathway increases the amount of Ca removed by that pathway, with corresponding changes in Ca efflux from the bulk cytoplasm. The magnitude of these effects varies with the proportion of the total Ca removed from the cytoplasm by that pathway. Differences in the response toEGTA and BAPTA, including changes in Ca-dependent inactivation of the L-type Ca current, resulted from the buffers acting as slow and fast ?shuttles, respectively, removing Ca from the dyadic space. The data suggest that complex changes i

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BO - Biofyzika

OECD FORD obor

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Projekt

<a href="/cs/project/NT14301" target="_blank" >NT14301: Vliv ethanolu a jeho metabolitu acetaldehydu na srdeční inward rectifier draslíkové proudy: vztah k fibrilaci síní po konzumaci alkoholu?</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BioMed Research International

ISSN

2314-6133

e-ISSN

—

Svazek periodika

2014

Číslo periodika v rámci svazku

2014

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

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Kód UT WoS článku

000337478800001

EID výsledku v databázi Scopus

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