Dual effect of ethanol on inward rectifier potassium current IK1 in rat ventricular myocytes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388998%3A_____%2F14%3A00431713" target="_blank" >RIV/61388998:_____/14:00431713 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26220/14:PU111652 RIV/00216224:14110/14:00080144

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Dual effect of ethanol on inward rectifier potassium current IK1 in rat ventricular myocytes

Popis výsledku v původním jazyce

Alcohol consumption may result in electrocardiographic changes and arrhythmias. Important role of modifications of the inward rectifier potassium current IK1 in arrhythmogenesis is well established. Considering lack of relevant data, we aimed at studyingthe effect of 0.2?200 mM ethanol on IK1 in enzymatically isolated rat right ventricular myocytes using the whole cell patch-clamp technique at 231°C. Ethanol reversibly affected IK1 in a dual way. At a very low concentration of 0.8 mM (0.004%), ethanolsignificantly decreased IK1 by 6.92.7%. However, at concentrations of ethanol higher than 8 mM (0.04%), IK1 was conversely significantly increased (by 16.64.0% at 20 mM and 24.52.4% at 80 mM). The steady-state IK1 increase was regularly preceded by its transient decrease at the beginning of ethanol application. Under 2 and 8 mM ethanol, IK1 was decreased at the steady-state in some cells but increased in others. Both effects were voltage-independent. In agreement with the observed effect

Název v anglickém jazyce

Dual effect of ethanol on inward rectifier potassium current IK1 in rat ventricular myocytes

Popis výsledku anglicky

Alcohol consumption may result in electrocardiographic changes and arrhythmias. Important role of modifications of the inward rectifier potassium current IK1 in arrhythmogenesis is well established. Considering lack of relevant data, we aimed at studyingthe effect of 0.2?200 mM ethanol on IK1 in enzymatically isolated rat right ventricular myocytes using the whole cell patch-clamp technique at 231°C. Ethanol reversibly affected IK1 in a dual way. At a very low concentration of 0.8 mM (0.004%), ethanolsignificantly decreased IK1 by 6.92.7%. However, at concentrations of ethanol higher than 8 mM (0.04%), IK1 was conversely significantly increased (by 16.64.0% at 20 mM and 24.52.4% at 80 mM). The steady-state IK1 increase was regularly preceded by its transient decrease at the beginning of ethanol application. Under 2 and 8 mM ethanol, IK1 was decreased at the steady-state in some cells but increased in others. Both effects were voltage-independent. In agreement with the observed effect

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BO - Biofyzika

OECD FORD obor

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Projekt

<a href="/cs/project/NT14301" target="_blank" >NT14301: Vliv ethanolu a jeho metabolitu acetaldehydu na srdeční inward rectifier draslíkové proudy: vztah k fibrilaci síní po konzumaci alkoholu?</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Physiology and Pharmacology

ISSN

0867-5910

e-ISSN

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Svazek periodika

65

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

13

Strana od-do

497-509

Kód UT WoS článku

000343017300005

EID výsledku v databázi Scopus

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