High frequency ultrasound assesses transient changes in cartilage under osmotic loading
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388998%3A_____%2F20%3A00537892" target="_blank" >RIV/61388998:_____/20:00537892 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/68407700:21340/20:00344684
Výsledek na webu
<a href="http://www.aimspress.com/article/10.3934/mbe.2020281" target="_blank" >http://www.aimspress.com/article/10.3934/mbe.2020281</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3934/mbe.2020281" target="_blank" >10.3934/mbe.2020281</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
High frequency ultrasound assesses transient changes in cartilage under osmotic loading
Popis výsledku v původním jazyce
High-frequency ultrasound is used in this study to measure noninvasively, by means of osmotic loading, changes in speed of sound and cartilage thickness caused by variations of the salt concentration in the external bath. Articular cartilage comprises three main structural components: Water, collagen fibrils and proteoglycan macromolecules carrying negative charges. The negatively charged groups of proteoglycans attract cations and water into tissue and govern its shrinkage/swelling behavior, which is a fundamental mechano-electrochemical function of cartilage tissue. In this study, the mechano-electrochemical behavior of cartilage is modeled by a diffusion model. The proposed model enables simulations of cartilage osmotic loading under various parameter settings and allows to quantify cartilage mechanical properties. This theoretical model is derived from the kinetic theory of diffusion. The objectives of the study are to quantify time dependent changes in cartilage thickness, and in speed of sound within tissue with help of the finite element based simulations and data from experiments. Experimental data are obtained from fresh and trypsinized ovine patella samples. Results show that the proposed diffusion model is capable to describe transient osmotic loading of cartilage. Mean values and their deviations of the relative changes of cartilage characteristics in response to chemical loading are presented.
Název v anglickém jazyce
High frequency ultrasound assesses transient changes in cartilage under osmotic loading
Popis výsledku anglicky
High-frequency ultrasound is used in this study to measure noninvasively, by means of osmotic loading, changes in speed of sound and cartilage thickness caused by variations of the salt concentration in the external bath. Articular cartilage comprises three main structural components: Water, collagen fibrils and proteoglycan macromolecules carrying negative charges. The negatively charged groups of proteoglycans attract cations and water into tissue and govern its shrinkage/swelling behavior, which is a fundamental mechano-electrochemical function of cartilage tissue. In this study, the mechano-electrochemical behavior of cartilage is modeled by a diffusion model. The proposed model enables simulations of cartilage osmotic loading under various parameter settings and allows to quantify cartilage mechanical properties. This theoretical model is derived from the kinetic theory of diffusion. The objectives of the study are to quantify time dependent changes in cartilage thickness, and in speed of sound within tissue with help of the finite element based simulations and data from experiments. Experimental data are obtained from fresh and trypsinized ovine patella samples. Results show that the proposed diffusion model is capable to describe transient osmotic loading of cartilage. Mean values and their deviations of the relative changes of cartilage characteristics in response to chemical loading are presented.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30304 - Public and environmental health
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Mathematical Biosciences and Engineering
ISSN
1547-1063
e-ISSN
—
Svazek periodika
17
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
22
Strana od-do
5190-5211
Kód UT WoS článku
000573692900006
EID výsledku v databázi Scopus
2-s2.0-85093360017