Kontrola kvality nenosičově přidaného (YCl3)-Y-90 určením efektivity značení pomocí jeho reakce s DOTATOC

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F08%3A00314519" target="_blank" >RIV/61389005:_____/08:00314519 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389005:_____/08:00358999

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Quality control of no-carrier-added (YCl3)-Y-90 by estimating the labeling efficiency using its reaction with DOTATOC

Popis výsledku v původním jazyce

The (YCl3)-Y-90 radionuclide precursor (solution of Y-90(3+) in diluted HCl) of high purity and high specific activity is already commercially produced and successfully used in nuclear medicine. At the Nuclear Physics Institute ASCR, the (YCl3)-Y-90 radionuclide precursor is prepared using extraction (SrY)-Sr-90-Y-90 generator (technology of centrifuge extractors with di-2-ethylhexylphosphoric acid, D2EHPA).(1) Its radionuclidic, radiochemical, and chemical purity were examined and specified. The procedure developed for labeling of DOTA-Tyr(3)-octreotide (DOTATOC) with carrier-free Y-86/90 by ROSCH2 at the Institute of Nuclear Chemistry of the University Mainz was optimized and modified in our Department of Radiopharmaceuticals at NPI ASCR as standardlabeling test (SLT) for analytical purposes. The SLT as a method for (YCl3)-Y-90 radionuclide precursor quality control determining its labeling efficiency using ITLC SG chromatography is described and proposed thereinafter.

Název v anglickém jazyce

Quality control of no-carrier-added (YCl3)-Y-90 by estimating the labeling efficiency using its reaction with DOTATOC

Popis výsledku anglicky

The (YCl3)-Y-90 radionuclide precursor (solution of Y-90(3+) in diluted HCl) of high purity and high specific activity is already commercially produced and successfully used in nuclear medicine. At the Nuclear Physics Institute ASCR, the (YCl3)-Y-90 radionuclide precursor is prepared using extraction (SrY)-Sr-90-Y-90 generator (technology of centrifuge extractors with di-2-ethylhexylphosphoric acid, D2EHPA).(1) Its radionuclidic, radiochemical, and chemical purity were examined and specified. The procedure developed for labeling of DOTA-Tyr(3)-octreotide (DOTATOC) with carrier-free Y-86/90 by ROSCH2 at the Institute of Nuclear Chemistry of the University Mainz was optimized and modified in our Department of Radiopharmaceuticals at NPI ASCR as standardlabeling test (SLT) for analytical purposes. The SLT as a method for (YCl3)-Y-90 radionuclide precursor quality control determining its labeling efficiency using ITLC SG chromatography is described and proposed thereinafter.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/FT-TA2%2F081" target="_blank" >FT-TA2/081: *Cílená superkancerostatika nové generace pro léčbu leukémií.</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Radioanalytical and Nuclear Chemistry

ISSN

0236-5731

e-ISSN

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Svazek periodika

278

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

5

Strana od-do

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Kód UT WoS článku

000259863400004

EID výsledku v databázi Scopus

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