Study of gold nanoparticles for mammography diagnostic and radiotherapy improvements

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F19%3A00508934" target="_blank" >RIV/61389005:_____/19:00508934 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.rpor.2019.07.005" target="_blank" >https://doi.org/10.1016/j.rpor.2019.07.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.rpor.2019.07.005" target="_blank" >10.1016/j.rpor.2019.07.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Study of gold nanoparticles for mammography diagnostic and radiotherapy improvements

Popis výsledku v původním jazyce

Aim: A study on the possibility to use gold nanoparticles in mammography, both for a better image diagnostics and radiotherapy, is presented and discussed. We evaluate quantitatively the increment of dose released to the tumor enriched with Au-NPs with respect to the near healthy tissues, finding that for X-rays the increase can reach two orders of greater intensity.nnBackground: Gold nanoparticles continue to be investigated for their potential to improve existing therapies and to develop novel therapies. They are simple to obtain, can be functionalized with different chemical approaches, are stable, non-toxic, non-immunogenic and have high permeability and retention effects in the tumor cells. The possibility to use these for breast calcified tumors to be better treated by radiotherapy is presented as a possible method to destroy the tumor.nnMaterials and methods: The nanoparticles can be generated in water using the top-down method, should have a size of the order of 10-20 nm and be treated to avoid their coalescence. Under diagnostic X-ray monitoring, the solution containing nanoparticles can be injected locally inside the tumor site avoiding injection in healthy tissues. The concentrations that can be used should be of the order of 10 mg/ml or higher.nnResults: An enhancement of the computerized tomography diagnostics using 80-150 key energy is expected, due to the higher mass X-ray coefficient attenuation with respect to other contrast media. Due to the increment of the effective atomic number of the biological tissue containing the gold nanoparticles, also an improvement of the radiotherapy effect using about 30 keV X-ray energy is expected, due to the higher photoelectric cross sections involved.nnConclusions: The study carried out represents a feasibility proposal for the use of Aunanoparticles for mammographic molecular imaging aimed at radiotherapy of tumor nodules but no clinical results are presented.

Název v anglickém jazyce

Study of gold nanoparticles for mammography diagnostic and radiotherapy improvements

Popis výsledku anglicky

Aim: A study on the possibility to use gold nanoparticles in mammography, both for a better image diagnostics and radiotherapy, is presented and discussed. We evaluate quantitatively the increment of dose released to the tumor enriched with Au-NPs with respect to the near healthy tissues, finding that for X-rays the increase can reach two orders of greater intensity.nnBackground: Gold nanoparticles continue to be investigated for their potential to improve existing therapies and to develop novel therapies. They are simple to obtain, can be functionalized with different chemical approaches, are stable, non-toxic, non-immunogenic and have high permeability and retention effects in the tumor cells. The possibility to use these for breast calcified tumors to be better treated by radiotherapy is presented as a possible method to destroy the tumor.nnMaterials and methods: The nanoparticles can be generated in water using the top-down method, should have a size of the order of 10-20 nm and be treated to avoid their coalescence. Under diagnostic X-ray monitoring, the solution containing nanoparticles can be injected locally inside the tumor site avoiding injection in healthy tissues. The concentrations that can be used should be of the order of 10 mg/ml or higher.nnResults: An enhancement of the computerized tomography diagnostics using 80-150 key energy is expected, due to the higher mass X-ray coefficient attenuation with respect to other contrast media. Due to the increment of the effective atomic number of the biological tissue containing the gold nanoparticles, also an improvement of the radiotherapy effect using about 30 keV X-ray energy is expected, due to the higher photoelectric cross sections involved.nnConclusions: The study carried out represents a feasibility proposal for the use of Aunanoparticles for mammographic molecular imaging aimed at radiotherapy of tumor nodules but no clinical results are presented.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Reports of Practical Oncology and Radiotherapy.

ISSN

1507-1367

e-ISSN

—

Svazek periodika

24

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

450-457

Kód UT WoS článku

000485766400006

EID výsledku v databázi Scopus

2-s2.0-85069869907