Nuclear reactions for protontherapy intensification

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F21%3A00539438" target="_blank" >RIV/61389005:_____/21:00539438 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.nimb.2020.11.002" target="_blank" >https://doi.org/10.1016/j.nimb.2020.11.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.nimb.2020.11.002" target="_blank" >10.1016/j.nimb.2020.11.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nuclear reactions for protontherapy intensification

Popis výsledku v původním jazyce

This paper presents some experimental results about the Li-7, B-11 and F-19 (p, alpha) nuclear reactions developed using proton beams at energy below 3 MeV in order to be applied to protontherapy. The energy released by proton beams during radiotherapy acts mainly at the end of the proton path in the biological medium, where it increases at high density inside the tumor. At this depth, it is possible to inject in the tumor compounds containing Li, B and F to generate energetic alpha particles from nuclear reactions. At the proton Bragg peak position it is possible to produce 1-8 MeV alpha particles, which enhance the energy density deposited in the tumor increasing the probability to damage the cells. Thanks to the higher relative biological efficiency of the alpha particles with respect to protons, it is expected that the alpha synergic particles defeat the tumor at lower doses.

Název v anglickém jazyce

Nuclear reactions for protontherapy intensification

Popis výsledku anglicky

This paper presents some experimental results about the Li-7, B-11 and F-19 (p, alpha) nuclear reactions developed using proton beams at energy below 3 MeV in order to be applied to protontherapy. The energy released by proton beams during radiotherapy acts mainly at the end of the proton path in the biological medium, where it increases at high density inside the tumor. At this depth, it is possible to inject in the tumor compounds containing Li, B and F to generate energetic alpha particles from nuclear reactions. At the proton Bragg peak position it is possible to produce 1-8 MeV alpha particles, which enhance the energy density deposited in the tumor increasing the probability to damage the cells. Thanks to the higher relative biological efficiency of the alpha particles with respect to protons, it is expected that the alpha synergic particles defeat the tumor at lower doses.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10304 - Nuclear physics

Projekt

<a href="/cs/project/GA19-02482S" target="_blank" >GA19-02482S: Syntéza pokročilých mikrostruktur v inovativních polymerech a nanokompozitech metodou mikrostrukturování iontovým svazkem</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nuclear Instruments & Methods in Physics Research Section B

ISSN

0168-583X

e-ISSN

1872-9584

Svazek periodika

486

Číslo periodika v rámci svazku

JAN

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

28-36

Kód UT WoS článku

000595666300005

EID výsledku v databázi Scopus

2-s2.0-85095966842