Gene Expression Changes in Irradiated Baboons: A Summary and Interpretation of a Decade of Findings

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F21%3A00543913" target="_blank" >RIV/61389005:_____/21:00543913 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/21:10428648 RIV/60162694:G44__/21:00557031 RIV/00179906:_____/21:10428648

Výsledek na webu

<a href="https://doi.org/10.1667/RADE-20-00217.1" target="_blank" >https://doi.org/10.1667/RADE-20-00217.1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1667/RADE-20-00217.1" target="_blank" >10.1667/RADE-20-00217.1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Gene Expression Changes in Irradiated Baboons: A Summary and Interpretation of a Decade of Findings

Popis výsledku v původním jazyce

Systematic analysis of 17 baboons helped us to identify limitations and to improve our methodology. Analysis using a two-step study design proved to be very powerful and can be recommended for future studies, with some cautions about multiple comparisons. The final design of our diagnostic tool proposed for H-ARS prediction exemplified the need to combine in vivo with in vitro studies and to bridge the inter-species gap by assessing several species and to compare that with findings in irradiated patient populations and healthy humans. In particular, our baboon research related to topics of radiosensitivity, whole-or partial-body exposure and persistent gene expression changes observed months after irradiation appears promising, but preliminary and further validation, as always, is crucial. The maturation grade of these topics cannot be compared with the main focus of our research on H-ARS prediction as our measure for preparedness for a radiological or nuclear event.

Název v anglickém jazyce

Gene Expression Changes in Irradiated Baboons: A Summary and Interpretation of a Decade of Findings

Popis výsledku anglicky

Systematic analysis of 17 baboons helped us to identify limitations and to improve our methodology. Analysis using a two-step study design proved to be very powerful and can be recommended for future studies, with some cautions about multiple comparisons. The final design of our diagnostic tool proposed for H-ARS prediction exemplified the need to combine in vivo with in vitro studies and to bridge the inter-species gap by assessing several species and to compare that with findings in irradiated patient populations and healthy humans. In particular, our baboon research related to topics of radiosensitivity, whole-or partial-body exposure and persistent gene expression changes observed months after irradiation appears promising, but preliminary and further validation, as always, is crucial. The maturation grade of these topics cannot be compared with the main focus of our research on H-ARS prediction as our measure for preparedness for a radiological or nuclear event.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Radiation Research

ISSN

0033-7587

e-ISSN

1938-5404

Svazek periodika

195

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

21

Strana od-do

501-521

Kód UT WoS článku

000658386600001

EID výsledku v databázi Scopus

2-s2.0-85107603708