Boron-Enhanced Biological Effectiveness of Proton Irradiation: Strategy to Assess the Underpinning Mechanism

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F22%3A00560656" target="_blank" >RIV/61389005:_____/22:00560656 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21340/22:00359662

Výsledek na webu

<a href="https://doi.org/10.1093/rpd/ncac093" target="_blank" >https://doi.org/10.1093/rpd/ncac093</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/rpd/ncac093" target="_blank" >10.1093/rpd/ncac093</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Boron-Enhanced Biological Effectiveness of Proton Irradiation: Strategy to Assess the Underpinning Mechanism

Popis výsledku v původním jazyce

Proton radiotherapy for the treatment of cancer offers an excellent dose distribution. Cellular experiments have shown that in terms of biological effects, the sharp dose distribution is further amplified, by as much as 75%, in the presence of boron. It is a matter of debate whether the underlying physical processes involve the nuclear reaction of B-11 with protons or B-10 with secondary neutrons, both producing densely ionizing short-ranged particles. Likewise, potential roles of intercellular communication or boron acting as a radiosensitizer are not clear. We present an ongoing research project based on a multiscale approach to elucidate the mechanism by which boron enhances the effectiveness of proton irradiation in the Bragg peak. It combines experimental with simulation tools to study the physics of proton-boron interactions, and to analyze intra- and inter-cellular boron biology upon proton irradiation.

Název v anglickém jazyce

Boron-Enhanced Biological Effectiveness of Proton Irradiation: Strategy to Assess the Underpinning Mechanism

Popis výsledku anglicky

Proton radiotherapy for the treatment of cancer offers an excellent dose distribution. Cellular experiments have shown that in terms of biological effects, the sharp dose distribution is further amplified, by as much as 75%, in the presence of boron. It is a matter of debate whether the underlying physical processes involve the nuclear reaction of B-11 with protons or B-10 with secondary neutrons, both producing densely ionizing short-ranged particles. Likewise, potential roles of intercellular communication or boron acting as a radiosensitizer are not clear. We present an ongoing research project based on a multiscale approach to elucidate the mechanism by which boron enhances the effectiveness of proton irradiation in the Bragg peak. It combines experimental with simulation tools to study the physics of proton-boron interactions, and to analyze intra- and inter-cellular boron biology upon proton irradiation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

<a href="/cs/project/GA21-06451S" target="_blank" >GA21-06451S: Záhada zvýšení buněčné odezvy indukované protony v přítomnosti boru</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Radiation Protection Dosimetry

ISSN

0144-8420

e-ISSN

1742-3406

Svazek periodika

198

Číslo periodika v rámci svazku

9-11

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

527-531

Kód UT WoS článku

000844405700006

EID výsledku v databázi Scopus

2-s2.0-85160074082