Radium targets for cyclotron production of 225Ac in view of targeted alpha therapy
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F23%3A00579004" target="_blank" >RIV/61389005:_____/23:00579004 - isvavai.cz</a>
Výsledek na webu
<a href="https://doi.org/10.1007/s00259-023-06333-x" target="_blank" >https://doi.org/10.1007/s00259-023-06333-x</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Radium targets for cyclotron production of 225Ac in view of targeted alpha therapy
Popis výsledku v původním jazyce
Targeted alpha therapy using the radionuclide Ac-225 has shown remarkable beneft in clinical trials to patients sufering from various cancer types. Currently most Ac-225 is produced from a few sources of Th-229 existing worldwide. However, the total amount available is only sufcient for a few thousand patient doses. Given a projected demand that is several orders of magnitude higher, alternative paths for the production of Ac-225 must be developed. We have been investigating the routenusing the Ra-226(p,2n)Ac-225 reaction. It is particularly attractive due to its large cross-section near 17 MeV proton energy and because it can be readily employed at a large number of cyclotron facilities. The excitation function of this reaction has been previously measured by us for a few energies, but discrepancies with calculations remain. Hence, new irradiation experiments are required to improve the knowledge of the excitation function to support the industrial production of Ac-225 via this route.
Název v anglickém jazyce
Radium targets for cyclotron production of 225Ac in view of targeted alpha therapy
Popis výsledku anglicky
Targeted alpha therapy using the radionuclide Ac-225 has shown remarkable beneft in clinical trials to patients sufering from various cancer types. Currently most Ac-225 is produced from a few sources of Th-229 existing worldwide. However, the total amount available is only sufcient for a few thousand patient doses. Given a projected demand that is several orders of magnitude higher, alternative paths for the production of Ac-225 must be developed. We have been investigating the routenusing the Ra-226(p,2n)Ac-225 reaction. It is particularly attractive due to its large cross-section near 17 MeV proton energy and because it can be readily employed at a large number of cyclotron facilities. The excitation function of this reaction has been previously measured by us for a few energies, but discrepancies with calculations remain. Hence, new irradiation experiments are required to improve the knowledge of the excitation function to support the industrial production of Ac-225 via this route.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
30224 - Radiology, nuclear medicine and medical imaging
Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů