Low temperature aqueous living/controlled (RAFT) polymerization of carboxybetaine methacrylamide up to high molecular weights

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F11%3A00360784" target="_blank" >RIV/61389013:_____/11:00360784 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/marc.201100176" target="_blank" >http://dx.doi.org/10.1002/marc.201100176</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/marc.201100176" target="_blank" >10.1002/marc.201100176</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Low temperature aqueous living/controlled (RAFT) polymerization of carboxybetaine methacrylamide up to high molecular weights

Popis výsledku v původním jazyce

Poly(carboxybetaine)s (poly(CB)s) are unique, emerging as the only ultra-low fouling materials allowing the preparation of biosensors, fouling resistant nanoparticles, and non-adhesive surfaces for bacteria. Poly(CB)s have been prepared via atom transferradical polymerization, however no control was achieved. Herein, the first successful living/controlled reversible addition fragmentation transfer polymerization of (3-methacryloylamino-propyl)-(2-carboxy-ethyl)-dimethyl-ammonium in acetate buffer (pH 5.2) at 70 and 37?°C is reported. The polymerization afforded very high molecular weight polymers (250?000 g??mol1 in less than 6?h) with low PDI (<1.3) at 70?°C. The polymerization was additionally carried out at 37?°C achieving yet lower PDIs (1.06??PDI??1.15) even at 90% conversion, demonstrating the suitability of the polymerization conditions for bioconjugate grafting. Block copolymerization from biologically relevant poly[HPMA] macroCTAs was additionally performed.

Název v anglickém jazyce

Low temperature aqueous living/controlled (RAFT) polymerization of carboxybetaine methacrylamide up to high molecular weights

Popis výsledku anglicky

Poly(carboxybetaine)s (poly(CB)s) are unique, emerging as the only ultra-low fouling materials allowing the preparation of biosensors, fouling resistant nanoparticles, and non-adhesive surfaces for bacteria. Poly(CB)s have been prepared via atom transferradical polymerization, however no control was achieved. Herein, the first successful living/controlled reversible addition fragmentation transfer polymerization of (3-methacryloylamino-propyl)-(2-carboxy-ethyl)-dimethyl-ammonium in acetate buffer (pH 5.2) at 70 and 37?°C is reported. The polymerization afforded very high molecular weight polymers (250?000 g??mol1 in less than 6?h) with low PDI (<1.3) at 70?°C. The polymerization was additionally carried out at 37?°C achieving yet lower PDIs (1.06??PDI??1.15) even at 90% conversion, demonstrating the suitability of the polymerization conditions for bioconjugate grafting. Block copolymerization from biologically relevant poly[HPMA] macroCTAs was additionally performed.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Macromolecular Rapid Communications

ISSN

1022-1336

e-ISSN

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Svazek periodika

32

Číslo periodika v rámci svazku

13

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

958-965

Kód UT WoS článku

000292547100003

EID výsledku v databázi Scopus

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