Multicompartment lipid nanocarriers for targeting of cells expressing brain receptors

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Multicompartment lipid nanocarriers for targeting of cells expressing brain receptors

Popis výsledku v původním jazyce

Neurotrophic factors, such as the brain-derived neurotrophic factor (BDNF), are essential for the development and survival of human neurons. Their encapsulation in carrier lipid systems is anticipated to overcome the problems resulting from the pharmacokinetics of peptides in the cerebral circulation. Lipid nanocarriers containing an omega-3 polyunsaturated fatty acid, should trigger the BDNF activity. The purpose of this study is to design and characterize self-assembled lipid systems suitable for encapsulation and potentialization of neurotrophic peptide activity and study of multicompartment liquid crystalline formulations in vitro on a human neuronal cell line expressing BDNF receptors. Sterically stabilized nanodispersed lipid systems are preparedfrom a PEGylated (polyethylene glycol) liquid crystalline phase in excess water. Such lipid nanovectors are of ongoing interest due to their biocompatible compositions and the relatively low energy input required for their manufacture.

Název v anglickém jazyce

Multicompartment lipid nanocarriers for targeting of cells expressing brain receptors

Popis výsledku anglicky

Neurotrophic factors, such as the brain-derived neurotrophic factor (BDNF), are essential for the development and survival of human neurons. Their encapsulation in carrier lipid systems is anticipated to overcome the problems resulting from the pharmacokinetics of peptides in the cerebral circulation. Lipid nanocarriers containing an omega-3 polyunsaturated fatty acid, should trigger the BDNF activity. The purpose of this study is to design and characterize self-assembled lipid systems suitable for encapsulation and potentialization of neurotrophic peptide activity and study of multicompartment liquid crystalline formulations in vitro on a human neuronal cell line expressing BDNF receptors. Sterically stabilized nanodispersed lipid systems are preparedfrom a PEGylated (polyethylene glycol) liquid crystalline phase in excess water. Such lipid nanovectors are of ongoing interest due to their biocompatible compositions and the relatively low energy input required for their manufacture.

Druh

C - Kapitola v odborné knize

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Self-assembled supramolecular architectures: Lyotropic liquid crystals

ISBN

978-0-470-28175-8

Počet stran výsledku

37

Strana od-do

319-355

Počet stran knihy

396

Název nakladatele

John Wiley & Sons

Místo vydání

Hoboken

Kód UT WoS kapitoly

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