Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: a step forward

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F13%3A00399466" target="_blank" >RIV/61389013:_____/13:00399466 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.colsurfa.2013.08.056" target="_blank" >http://dx.doi.org/10.1016/j.colsurfa.2013.08.056</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.colsurfa.2013.08.056" target="_blank" >10.1016/j.colsurfa.2013.08.056</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: a step forward

Popis výsledku v původním jazyce

Surfactant-free PLGA polymeric nanoparticles (PNPs) with hydrodynamic radius (RH) ranging from 25.8 nm to 128.5 nm were successfully obtained through nanoprecipitation by controlling a variety of physicochemical parameters. The size of the generated PLGAPNPs could be controlled by adjusting the polymer concentration, the choice of organic solvent, mixing different organic solvents or by changing temperature and ionic strength. By optimizing such parameters sub-100 nm uniform PNPs can be produced through this methodology including the advantage and ability to scale-up production. The PNPs have shown a size-dependent effect on the organic solvent and polymer concentration. On the other hand, the polymer?solvent interactions seem not to play a substantial role in the final dimension of the polymer colloids. It has been also evidenced that the size of PNPs can be precisely and linearly tuned by using solvent mixtures as organic phase.

Název v anglickém jazyce

Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: a step forward

Popis výsledku anglicky

Surfactant-free PLGA polymeric nanoparticles (PNPs) with hydrodynamic radius (RH) ranging from 25.8 nm to 128.5 nm were successfully obtained through nanoprecipitation by controlling a variety of physicochemical parameters. The size of the generated PLGAPNPs could be controlled by adjusting the polymer concentration, the choice of organic solvent, mixing different organic solvents or by changing temperature and ionic strength. By optimizing such parameters sub-100 nm uniform PNPs can be produced through this methodology including the advantage and ability to scale-up production. The PNPs have shown a size-dependent effect on the organic solvent and polymer concentration. On the other hand, the polymer?solvent interactions seem not to play a substantial role in the final dimension of the polymer colloids. It has been also evidenced that the size of PNPs can be precisely and linearly tuned by using solvent mixtures as organic phase.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BO - Biofyzika

OECD FORD obor

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Projekt

<a href="/cs/project/GA202%2F09%2F2078" target="_blank" >GA202/09/2078: Bioinspirované nanočástice reagující na změny vnějšího prostředí</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Colloids and Surfaces. A - Physicochemical and Engineering Aspects

ISSN

0927-7757

e-ISSN

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Svazek periodika

436

Číslo periodika v rámci svazku

5 September

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

1092-1102

Kód UT WoS článku

000326416900135

EID výsledku v databázi Scopus

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