Hepatocyte growth on polycapronolactone and 2-hydroxyethylmethacrylate nanofiber sheets enhanced by bone marrow-derived mesenchymal stromal cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F13%3A00420631" target="_blank" >RIV/61389013:_____/13:00420631 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/13:00420631 RIV/61383082:_____/13:0029

Výsledek na webu

<a href="http://dx.doi.org/10.5754/hge11948" target="_blank" >http://dx.doi.org/10.5754/hge11948</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5754/hge11948" target="_blank" >10.5754/hge11948</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hepatocyte growth on polycapronolactone and 2-hydroxyethylmethacrylate nanofiber sheets enhanced by bone marrow-derived mesenchymal stromal cells

Popis výsledku v původním jazyce

The development of Bioartificial Liver Assist Devices (BLADs), intended for the therapy of chronic and fulminant liver failure, is one of the most important tasks in the area of tissue engineering. The primary objective of our research was to examine theinteractions of cell cultures (hepatocytes, bone marrow mesenchynal stromal cell mixed cultures) with nanofiber-based materials, which can be utilized as carriers for high density cultures, and to test the possibility of creating a polarized hepatocyteculture on a nanofiber layer., separating two compartments with a different composition of the cultivation medium (simulating the capillary and bile compartments of the hepatic tissue). The results reported demonstrate that nonwoven nanofiber layers area suitable biocompatible support for functional, hepatocyte cultures and can be utilized in a laboratory bioreactor; mesenchymal stromal cells from bone marrow may be utilized in order to enhance hepatocyte functionality on the nanofiber

Název v anglickém jazyce

Hepatocyte growth on polycapronolactone and 2-hydroxyethylmethacrylate nanofiber sheets enhanced by bone marrow-derived mesenchymal stromal cells

Popis výsledku anglicky

The development of Bioartificial Liver Assist Devices (BLADs), intended for the therapy of chronic and fulminant liver failure, is one of the most important tasks in the area of tissue engineering. The primary objective of our research was to examine theinteractions of cell cultures (hepatocytes, bone marrow mesenchynal stromal cell mixed cultures) with nanofiber-based materials, which can be utilized as carriers for high density cultures, and to test the possibility of creating a polarized hepatocyteculture on a nanofiber layer., separating two compartments with a different composition of the cultivation medium (simulating the capillary and bile compartments of the hepatic tissue). The results reported demonstrate that nonwoven nanofiber layers area suitable biocompatible support for functional, hepatocyte cultures and can be utilized in a laboratory bioreactor; mesenchymal stromal cells from bone marrow may be utilized in order to enhance hepatocyte functionality on the nanofiber

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Hepato-Gastroenterology

ISSN

0172-6390

e-ISSN

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Svazek periodika

60

Číslo periodika v rámci svazku

125

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

8

Strana od-do

1156-1163

Kód UT WoS článku

000330327700039

EID výsledku v databázi Scopus

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