Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA nanoparticles: Part I. Effect of process variables on the mean size

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F14%3A00425219" target="_blank" >RIV/61389013:_____/14:00425219 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.3109/02652048.2013.814729" target="_blank" >http://dx.doi.org/10.3109/02652048.2013.814729</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/02652048.2013.814729" target="_blank" >10.3109/02652048.2013.814729</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA nanoparticles: Part I. Effect of process variables on the mean size

Popis výsledku v původním jazyce

PLGA (poly d,l-lactic-co-glycolic acid) nanoparticles (NPs) encapsulating magnetite nanoparticles (MNPs) along with a model drug human serum albumin (HSA) were prepared by double emulsion solvent evaporation method. This Part I will focus on size and size distribution of prepared NPs, whereas encapsulation efficiency will be discussed in Part II. It was found that mean hydrodynamic particle size was influenced by five important process variables. To explore their effects, a five-factorial, three-level experimental design and statistical analysis were carried out using STATISTICA software. Effect of process variables on the mean size of nanoparticles was investigated and finally conditions to minimize size of NPs were proposed. GAMS/MINOS software was used for optimization. The mean hydrodynamic size of nanoparticles ranged from 115 to 329?nm depending on the process conditions. Smallest possible mean particle size can be achieved by using low polymer concentration and high dispersion e

Název v anglickém jazyce

Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA nanoparticles: Part I. Effect of process variables on the mean size

Popis výsledku anglicky

PLGA (poly d,l-lactic-co-glycolic acid) nanoparticles (NPs) encapsulating magnetite nanoparticles (MNPs) along with a model drug human serum albumin (HSA) were prepared by double emulsion solvent evaporation method. This Part I will focus on size and size distribution of prepared NPs, whereas encapsulation efficiency will be discussed in Part II. It was found that mean hydrodynamic particle size was influenced by five important process variables. To explore their effects, a five-factorial, three-level experimental design and statistical analysis were carried out using STATISTICA software. Effect of process variables on the mean size of nanoparticles was investigated and finally conditions to minimize size of NPs were proposed. GAMS/MINOS software was used for optimization. The mean hydrodynamic size of nanoparticles ranged from 115 to 329?nm depending on the process conditions. Smallest possible mean particle size can be achieved by using low polymer concentration and high dispersion e

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

JB - Senzory, čidla, měření a regulace

OECD FORD obor

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Projekt

<a href="/cs/project/KAN401220801" target="_blank" >KAN401220801: Příprava nanostruktur a nanomaterialů s cíleným řízením rozměrů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Microencapsulation

ISSN

0265-2048

e-ISSN

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Svazek periodika

31

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

147-155

Kód UT WoS článku

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EID výsledku v databázi Scopus

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