Structural diversity of solid dispersions of acetylsalicylic acid as seen by solid-state NMR

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F14%3A00426114" target="_blank" >RIV/61389013:_____/14:00426114 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1021/mp400495h" target="_blank" >http://dx.doi.org/10.1021/mp400495h</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/mp400495h" target="_blank" >10.1021/mp400495h</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Structural diversity of solid dispersions of acetylsalicylic acid as seen by solid-state NMR

Popis výsledku v původním jazyce

Solid dispersions of active pharmaceutical ingredients are of increasing interest due to their versatile use. In the present study polyvinylpyrrolidone (PVP), poly[N-(2-hydroxypropyl)-metacrylamide] (pHPMA), poly(2-ethyl-2-oxazoline) (PEOx), and polyethylene glycol (PEG), each in three Mw, were used to demonstrate structural diversity of solid dispersions. Acetylsalicylic acid (ASA) was used as a model drug. The obtained structural data confirmed that the type of solid dispersion can be primarily controlled by the chemical constitutions of the applied polymers, while the molecular weight of the polymers had no detectable impact. The molecular structure of the prepared dispersions was characterized using solid-state NMR, wide-angle X-ray scattering (WAXS), and differential scanning calorimetry (DSC). By applying various 1H?13C and 1H?1H correlation experiments combined with T1(1H) and T1?(1H) relaxation data, the extent of the molecular mixing was determined over a wide range of distanc

Název v anglickém jazyce

Structural diversity of solid dispersions of acetylsalicylic acid as seen by solid-state NMR

Popis výsledku anglicky

Solid dispersions of active pharmaceutical ingredients are of increasing interest due to their versatile use. In the present study polyvinylpyrrolidone (PVP), poly[N-(2-hydroxypropyl)-metacrylamide] (pHPMA), poly(2-ethyl-2-oxazoline) (PEOx), and polyethylene glycol (PEG), each in three Mw, were used to demonstrate structural diversity of solid dispersions. Acetylsalicylic acid (ASA) was used as a model drug. The obtained structural data confirmed that the type of solid dispersion can be primarily controlled by the chemical constitutions of the applied polymers, while the molecular weight of the polymers had no detectable impact. The molecular structure of the prepared dispersions was characterized using solid-state NMR, wide-angle X-ray scattering (WAXS), and differential scanning calorimetry (DSC). By applying various 1H?13C and 1H?1H correlation experiments combined with T1(1H) and T1?(1H) relaxation data, the extent of the molecular mixing was determined over a wide range of distanc

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GPP106%2F11%2FP426" target="_blank" >GPP106/11/P426: Zvýšení biologické dostupnosti nerozpustných farmaceutických substancí působením polymerní matrice</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

MOLECULAR PHARMACEUTICS

ISSN

1543-8384

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

516-530

Kód UT WoS článku

000330812500015

EID výsledku v databázi Scopus

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